journal1 ›› 2019, Vol. 27 ›› Issue (11): 1201-1203.DOI: 10.11852/zgetbjzz2019-0099

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Correlations among lactose intolerance,calcium intake and bone health

WU Hai-lin, ZHAN Xue   

  1. Department of gastroenterology, Children′s Hospital Of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders; China International Science and Technology Cooperation base of Child development and Critical Disorders; Children′s Hospital of Chongqing Medical University, Chongqing, P.R China; Chongqing Key Laboratory of Pediatrics, Chongqing 400014,China
  • Received:2019-01-19 Online:2019-11-10 Published:2019-11-10
  • Contact: ZHAN Xue,


吴海霖 综述 , 詹学 审校   

  1. 重庆医科大学附属儿童医院消化内科,儿童发育疾病研究教育部重点实验室,国家儿童健康与疾病临床医学研究中心,儿童发育重大疾病国家国际科技合作基地,儿科学重庆市重点实验室,重庆400014
  • 通讯作者: 詹学,
  • 作者简介:吴海霖(1995-),男,福建人,硕士研究生,研究方向为营养消化。

Abstract: Lactose intolerance is considered to be concerned with calcium intake and bone health.It is generally believed that lactose intolerance can reduce calcium intake,but its effect on calcium absorption rate is still controversial.Lactose appears to be an important factor of calcium absorption among lactose intolerant populations,and different doses of lactose in earlier study designs may also be responsible for different results.In recent decades,lactase related gene types have been found to be an important factor affecting calcium intake and bone health.However,being limited by knowledge and technology,the heterogeneity among previous studies is large,which contributes to the contradictory data aggregation in related studies.So more reliable and larger samples of control studies are warranted in order to explore the correlation among lactose intolerance,calcium intake and bone health.

Key words: lactoseintolerance, lactosemalabsorption, calciumintake, calciumabsorption, bonehealth

摘要: 乳糖不耐受被认为与钙摄取和骨健康息息相关。目前普遍认为乳糖不耐受会降低钙摄入量,但对于钙吸收率的影响至今仍有较大的争议。在乳糖不耐受人群中,乳糖可能是影响钙吸收的重要因素,而早期研究设计中的不同乳糖剂量负荷也可能是导致不同结果的原因。而近十几年的研究发现乳糖酶相关基因类型是影响钙摄入与骨健康的重要因子。然而既往研究受限于知识技术的限制,研究内与研究间的异质性过大,这导致了相关研究出现相互矛盾的数据聚集。这也迫使当下进行更可靠的大样本对照研究来探讨乳糖不耐受与钙摄取和骨健康的相关性。

关键词: 乳糖不耐受, 乳糖吸收不良, 钙摄入, 钙吸收, 骨健康

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