Correlations among lactose intolerance,calcium intake and bone health

doi:10.11852/zgetbjzz2019-0099

Abstract

Abstract: Lactose intolerance is considered to be concerned with calcium intake and bone health.It is generally believed that lactose intolerance can reduce calcium intake,but its effect on calcium absorption rate is still controversial.Lactose appears to be an important factor of calcium absorption among lactose intolerant populations,and different doses of lactose in earlier study designs may also be responsible for different results.In recent decades,lactase related gene types have been found to be an important factor affecting calcium intake and bone health.However,being limited by knowledge and technology,the heterogeneity among previous studies is large,which contributes to the contradictory data aggregation in related studies.So more reliable and larger samples of control studies are warranted in order to explore the correlation among lactose intolerance,calcium intake and bone health.

Key words: lactoseintolerance, lactosemalabsorption, calciumintake, calciumabsorption, bonehealth

摘要： 乳糖不耐受被认为与钙摄取和骨健康息息相关。目前普遍认为乳糖不耐受会降低钙摄入量,但对于钙吸收率的影响至今仍有较大的争议。在乳糖不耐受人群中,乳糖可能是影响钙吸收的重要因素,而早期研究设计中的不同乳糖剂量负荷也可能是导致不同结果的原因。而近十几年的研究发现乳糖酶相关基因类型是影响钙摄入与骨健康的重要因子。然而既往研究受限于知识技术的限制,研究内与研究间的异质性过大,这导致了相关研究出现相互矛盾的数据聚集。这也迫使当下进行更可靠的大样本对照研究来探讨乳糖不耐受与钙摄取和骨健康的相关性。

关键词: 乳糖不耐受, 乳糖吸收不良, 钙摄入, 钙吸收, 骨健康

CLC Number:

R179

WU Hai-lin, ZHAN Xue. Correlations among lactose intolerance,calcium intake and bone health[J]. journal1, 2019, 27(11): 1201-1203.

吴海霖 , 詹学. 乳糖不耐受与钙摄取和骨健康研究进展[J]. 中国儿童保健杂志, 2019, 27(11): 1201-1203.

References

[1] Suchy FJ,Brannon PM,Carpenter TO,et al.NIH consensus development conference statement:lactose intolerance and health[J].Nih Consens State Sci Statements,2010,27(2):1-27.
[2] Stefano MDI,Veneto G,Malservisi S,et al.Lactose malabsorption and intolerance and peak bone mass[J].Gastroenterology,2002,122(7):1793-1799.
[3] Pawłowska K,Seredyński R,Umławska W,et al.Hydrogen excretion in pediatric lactose malabsorbers:relation to symptoms and the dose of lactose[J].Arch Med Sci,2018,14(1):88-93.
[4] Wilt TJ,Shaukat A,Shamliyan T,et al.Lactose intolerance and health[J].Evid Rep Technol Assess,2010,192(192):1-410.
[5] Laaksonen MM,Mikkila V,Rasanen L,et al.Genetic lactase non-persistence,consumption of milk products and intakes of milk nutrients in finns from childhood to young adulthood[J].Br J Nutr,2009,102(1):8-17.
[6] Zhao J,Fox M,Cong Y,et al.Lactose intolerance in patients with chronic functional diarrhoea:the role of small intestinal bacterial overgrowth[J] .Aliment Pharmacol Ther,2010,31(8):892-900.
[7] Tomba C,Baldassarri A,Coletta M,et al.Is the subjective perception of lactose intolerance influenced by the psychological profile?[J].Aliment Pharmacol Ther,2012,36(7):660-669.
[8] Jellema P,Schellevis FG,Dawm VAD,et al.Lactose malabsorption and intolerance:a systematic review on the diagnostic value of gastrointestinal symptoms and self-reported milk intolerance[J].QJM,2010,103(8):555-572.
[9] Tolonen S,Laaksonen M,Mikkila V,et al.Lactase gene c/t(-13910) polymorphism,calcium intake,and pQCT bone traits in finnish adults[J].Calcif Tissue Int,2011,88(2):153-161.
[10] Treister-Goltzman Y,Friger R,Peleg M.Does primary lactase deficiency reduce bone mineral density in postmenopausal women? A systematic review and meta-analysis[J].Osteoporosis Int,2018,1-9:2399-2407.
[11] Winzenberg TM,Shaw K,Fryer J,et al.Calcium supplementation for improving bone mineral density in children[J].Cochrane Database Syst Rev,2006,2:CD005119.
[12] Händel MN,Heitmann BL,Abrahamsen B.Nutrient and food intakes in early life and risk of childhood fractures:a systematic review and meta-analysis[J].Am J Clin Nutr,2015,102(5):1182-1195.
[13] Goulding A,Rockell JE,Black RE,et al.Children who avoid drinking cow′s milk are at increased risk for prepubertal bone fractures[J].J Am Diet Assoc,2004,104(2):250-253.
[14] Manias K,McCabe D,Bishop N.Fractures and recurrent fractures in children; varying effects of environmental factors as well as bone size and mass[J].Bone,2006,39(3):652-657.
[15] Pires LA,Souza AC,Laitano O,et al.Bone mineral density,milk intake and physical activity in boys who suffered forearm fractures[J].J Pediatr (Rio J),2005,81(4):332-336.
[16] Larson NI,Neumark-Sztainer D,Harnack L,et al.Calcium and dairy intake:Longitudinal trends during the transition to young adulthood and correlates of calcium intake[J].J Nutr Educ Behav,2009,41(4):254-260.
[17] BaldanA,Tagliati S,Saccomandi D,et al.Assessment of lactose-free diet on the phalangeal bone mineral status in italian adolescents affected by adult-type hypolactasia[J].Nutrients,2018,10(5):E558.
[18] Kwak HS,Lee WJ,Lee MR.Revisiting lactose as an enhancer of calcium absorption[J].Int Dairy J,2012,22(2):147-151.
[19] Obermayer-Pietsch BM,Gugatschka M,Reitter S,et al.Adult-type hypolactasia and calcium availability:decreased calcium intake or impaired calcium absorption?[J].Osteoporos Int,2007,18(4):445-451.
[20] Tremaine WJ,Newcomer AD,Riggs BL,et al.Calcium absorption from milk in lactase-deficient and lactase-sufficient adults[J].Dig Dis Sci,1986,31(4):376-378.
[21] Vandenplas Y.Lactose intolerance[J].Asia Pac J Clin Nutr,2015,24(Suppl):9-13.
[22] Griessen M,Cochet B,Infante F,et al.Calcium absorption from milk in lactase-deficient subjects[J].Am J Clin Nutr,1989,49(2):377.
[23] Saulnier DMA,Spinler JK,Gibson GR,et al.Mechanisms of probiosis and prebiosis:considerations for enhanced functional foods[J].Curr Opin Biotechnol,2009,20(2):135-141.
[24] Bronner F.Recent developments in intestinal calcium absorption[J].Nutr Rev,2010,67(2):109-113.
[25] Cochet B,Jung A,Griessen M,et al.Effects of lactose on intestinal calcium absorption in normal and lactase-deficient subjects[J].Gastroenterology,1983,84(5):935.
[26] Dawsonhughes B.Interaction of dietary calcium and protein in bone health in humans[J]. J Nutr,2003,133(Suppl 3):852-854.
[27] Bikle DD,Tahimic C,Chang W,et al.Role of IGF-I signaling in muscle bone interactions[J].Bone,2015,80:79-88.