Abstract: Objective To research the risk factors of ventricular hemorrhage in very low birth weight infants (VLBWI) and extremely low birth weight infants (ELBWI),in order to provide the basis for clinical treatment. Methods Clinical data of 185 inpatients with VLBWI and ELBWI from division of Neonatology,the Affiliated Hospital of Guangdong Medical University from July 2016 to July 2018 were collected.And factors which may cause ventricular hemorrhage were determined by single factor analysis and multivariate Logistic regression analysis. Results Logistic regression analysis showed that hypoglycemia (OR=8.772,95%CI:2.880―26.720,P＜0.01),low hematocrit(OR=0.211,95%CI:0.072―0.618,P=0.005),sepsis (OR=6.427,95%CI:2.306-17.911,P＜0.01) and mechanical ventilation (OR=2.984,95%CI:1.013-8.785,P=0.047) were independent risk factors for ventricular hemorrhage. Conclusionss Very low birth weight infants and extremely low birth weight infant are at a higher risk for intraventricular hemorrhage.Active prevention of hypoglycemia,low hemoglobin congestion,infection and reasonable mechanical ventilation can help reduce the occurrence of intraventricular hemorrhage in very low birth weight infants and extremely low birth weight infants.

Key words: ventricular hemorrhage, very low birth weight infant, extremely low birth infant, risk factor

摘要： 目的 分析极低出生体重儿和超低出生体重儿发生脑室出血的危险因素,为临床治疗提供依据。方法 收集2016年7月—2018年7月广东医科大学附属医院新生儿科住院的185例极低、超低出生体重患儿临床资料,对可能影响脑室出血的因素进行单因素分析和多因素Logistic回归分析。结果 Logistic回归分析显示,低血糖(OR=8.772,95%CI:2.880～26.720,P＜0.01)、低血细胞压积(OR=0.211,95%CI:0.072～0.618,P=0.005)、脓毒血症(OR=6.427,95%CI:2.306～17.911,P＜0.01)和机械通气(OR=2.984,95%CI:1.013～8.785,P=0.047)是脑室出血的独立危险因素。结论 极低出生体重儿和超低出生体重儿并发脑室出血的高危因素较多,积极预防低血糖、低血红蛋白压积、感染及合理的机械通气有助于减少极低出生体重儿和超低出生体重儿并发脑室出血。

关键词: 脑室出血, 极低出生体重儿, 超低出生体重儿, 危险因素