Chinese Journal of Child Health Care ›› 2022, Vol. 30 ›› Issue (11): 1216-1220.DOI: 10.11852/zgetbjzz2021-0627

Special Issue: 孤独症谱系障碍

• Review • Previous Articles     Next Articles

Research progress on intestinal microbes and their metabolites and autism spectrum disorder

LIU Huan*, WANG Suo-ying, LI Yu-qin, SUN Zhi-ming   

  1. *Department of Pediatrics, the Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, China
  • Received:2021-05-14 Revised:2021-08-02 Online:2022-11-10 Published:2022-11-09
  • Contact: WANG Suo-ying, E-mail: wsy8083@163.com; SUN Zhi-ming, E-mail:109616029@qq.com

肠道微生物及其代谢产物与孤独症谱系障碍的研究进展

刘欢1, 王锁英1, 李玉勤1, 孙志明2   

  1. 1.江苏大学附属医院儿科,江苏 镇江 212001;
    2.江苏省卫生健康发展研究中心
  • 通讯作者: 王锁英,E-mail:wsy8083@163.com;孙志明,E-mail:109616029@qq.com
  • 作者简介:刘欢(1996-),女,四川人,在读硕士研究生,主要研究方向为儿童保健,儿科内分泌。
  • 基金资助:
    江苏省人口学会开放基金资助项目(JSPA2019025)

Abstract: Currently, the underlying mechanisms of etiology and manifestations ofautism spectrum disorder (ASD) are still poorly understood.More and more studies have shown that changes in intestinal microbes and their metabolites (such as short-chain fatty acids, γ-aminobutyric acid, etc.) may be related to the pathogenesis of ASD.Therefore, this paper reviews the studies related to the changes and mechanisms of gut microbes and metabolites in ASD children, and analyzes the possible differences and associations of gut microbes and metabolites between ASD children and healthy children, in order to explore the influence of changes in intestinal microbes and their metabolites on children ASD, and to provide some new ideas for the diagnosis and treatment of ASD.

Key words: autism spectrum disorder, gut microbiota, metabolites, microbiome-gut-brain axis

摘要: 目前,孤独症谱系障碍(ASD)病因和表现的潜在机制仍然知之甚少。越来越多的研究表明,肠道微生物及其代谢产物(如短链脂肪酸、γ-氨基丁酸等)的改变可能与ASD的发病有关。因此,本文将ASD儿童肠道微生物和代谢物的变化及机制的相关研究进行综述,分析ASD儿童和健康儿童之间可能存在的肠道微生物与代谢产物的差异及联系,以探讨肠道微生物及其代谢物的变化对ASD患儿的影响,为ASD的诊断和治疗提供一些新的思路。

关键词: 孤独症谱系障碍, 肠道菌群, 代谢产物, 微生物-肠-脑轴

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