Abstract: Objective To explore the developmental trajectory of restricted and repetitive behavior (RRB) in children with autism spectrum disorder (ASD), and to determine whether there is a correlation between RRB and sensory gating, so as to provide reference for clinical diagnosis and treatment. Methods From August 2018 to May 2021, 89 children with ASD and 76 children with global developmental delay (GDD) in Children's Rehabilitation Department of the Fifth Affiliated Hospital of Zhengzhou University were selected into this study. RRB was assessment by the Repetitive Behavior Scale-Revised (RBS-R), and cerebral sensory gating was evaluated by the sensory gating P50 ratio, and the correlation was analyzed. Results There was no significant correlation of the total scores, low-level and high-level of RRB with sensory gating in ASD children and GDD children (P>0.05). There was no significant decrease with age in the total scores, low-level and high-level of RRB in ASD children (P>0.05). However, RRB score was negatively related to the age of children with GDD (r=-0.43 to -0.23, P<0.01). Conclusions The developmental trajectory of RRB in ASD children is not a simple negative linear curve with age. There is no significant correlation between RRB and sensory gating. P50 may not be an effective index to predict repetitive and stereotyped behaviors.

Key words: autism spectrum disorder, restricted and repetitive behaviors, sensory gating, P50

摘要： 目的 探究孤独症谱系障碍(ASD)儿童重复刻板行为的发育轨迹,明确其与大脑感觉门控之间的相关性,以期进一步为临床诊疗提供参考。方法 选取2018年8月—2021年5月就诊于郑州大学第五附属医院儿童康复科门诊符合ASD诊断儿童89例,符合全面性发育迟缓(GDD)诊断儿童76例,采用重复行为量表-修订版(RBS-R)评价患儿重复刻板行为,采用感觉门控P50比值评价患儿大脑感觉门控,并分析二者的相关性。结果 ASD及GDD儿童的重复刻板行为总分、低阶及高阶与感觉门控均无相关性(P＞0.05)。ASD儿童重复刻板行为总分、低阶及高阶得分随年龄增长未见明显下降趋势(P＞0.05),GDD儿童重复刻板行为与年龄呈明显负相关(r=-0.43~-0.23,P＜0.05)。结论 ASD儿童重复刻板行为发育轨迹并非简单的负性线性关系,其重复刻板行为与大脑感觉门控无明显相关性,P50可能不是一个有效预测重复刻板行为的指标。

关键词: 孤独症谱系障碍, 重复刻板行为, 感觉门控, P50