Abstract: Childhood obesity seriously endangers children's physical and mental health, and is increasingly prevalent. Most childhood obesity is still simple obesity, which is closely related to poor eating behaviors, especially excessive energy intake or dietary structure disorders (such as high sugar and high fat). With the prevalence of ultra-processed foods in recent decades, food sweeteners have become more diverse, have a more comprehensive application range, and have a sharply increased consumption. Food sweeteners have a long history, and are considered safe.However, growing evidence showed that excessive intake would interfere with the metabolism, whether it is natural sweeteners or artificial sweeteners.Therefore, long-term excessive intake of food sweeteners in children can significantly increase the risk of childhood obesity. This article mainly summarizes related researches on the influence of food sweeteners on metabolism,so as to provide reference for pediatricians.

Key words: sweeteners, artificial sweeteners, childhood obesity, metabolism

摘要： 儿童肥胖严重危害儿童身心健康,其流行态势日趋严峻。儿童肥胖大多数仍为单纯性肥胖,与不良饮食行为息息相关,尤其能量摄入过多或膳食结构失调(如高糖高脂)。近几十年随着超加工食品的普遍,食品甜味剂种类更为丰富,应用范围更广,消费量剧增。虽然食品甜味剂使用历史由来已久,大多数被认为是安全的;但越来越多证据显示,无论是天然甜味剂还是人造甜味剂,不合理摄入均可能会对机体代谢产生干扰。儿童长期或过量摄入食品甜味剂可增加儿童肥胖的风险。本文主要总结食品甜味剂对代谢影响的相关研究进展,以供各位同行参考。

关键词: 甜味剂, 人工甜味剂, 儿童肥胖, 代谢