Research advance on exosomes and neuropsychiatric disorders in children

doi:10.11852/zgetbjzz2022-1082

Abstract

Abstract: Exosomes are a bridge for intercellular information exchange and material transfer, and contain a variety of bioactive components that play an important role in neurodevelopment, immunity, tissue homeostasis, cancer, neurodegenerative diseases and neuropsychiatric disorders in children.This paper summarizes the biological characteristics and biological production of exosomes, points out the mechanism intervention or influencing factors of exosomes in children with common neuropsychiatric disorders such as autism spectrum disorder, epilepsy, schizophrenia, Tourette syndrome, and discusses the potential role of exosomes in the diagnosis, treatment and prognosis of children with neuropsychiatric disorders.The future treatment of children with neuropsychiatric disorders is prospected.

Key words: exosomes, neurodevelopment, neuroinflammation, immune system, neuropsychiatric disorders in children

摘要： 外泌体是一种可由多种细胞分泌的纳米级小囊泡,内含多种生物活性成分,是细胞间信息交流及物质传递的桥梁,在人类健康和疾病的许多方面扮演着重要的角色,包括神经发育、免疫、组织内稳态、癌症、神经退行性疾病和儿童神经精神障碍性疾病。近年来,由于外泌体在生物过程中的作用以及在儿童神经精神障碍的发展和进展中的作用,外泌体的调控被广泛研究。本文总结了外泌体的生物特性、生物产生,指出了外泌体对孤独症谱系障碍、癫痫、精神分裂症、Tourette综合征等儿童常见神经精神障碍性疾病中的机制干预或影响因素,探讨了外泌体在儿童神经精神障碍性疾病中诊断、治疗及预后生物标志物中的潜在作用,并对未来治疗相关儿童神经精神障碍性疾病中的前景做出了展望。

关键词: 外泌体, 神经发育, 神经炎症, 免疫系统, 儿童神经精神障碍性疾病

CLC Number:

R749.94

LIU Jiamin, ZHAO Sha, ZHONG Yan. Research advance on exosomes and neuropsychiatric disorders in children[J]. Chinese Journal of Child Health Care, 2023, 31(5): 521-525.

刘佳敏, 赵莎, 钟燕. 外泌体与儿童神经精神障碍的研究进展[J]. 中国儿童保健杂志, 2023, 31(5): 521-525.

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