Chinese Journal of Child Health Care ›› 2023, Vol. 31 ›› Issue (9): 986-989.DOI: 10.11852/zgetbjzz2022-1269

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Research advance in the role of gut microbiota in attention deficit hyperactivity disorder

ZHENG Jie, CHEN Yanhui   

  1. Department of Pediatrics, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, China
  • Received:2022-12-13 Revised:2023-02-22 Online:2023-09-10 Published:2023-08-31
  • Contact: CHEN Yanhui,


郑杰, 陈燕惠   

  1. 福建医科大学附属协和医院儿科,福建 福州 350001
  • 通讯作者: 陈燕惠,
  • 作者简介:郑杰(1991-),男,住院医师,医学硕士,主要研究方向为儿童神经与发育。
  • 基金资助:

Abstract: The microbial-gut-brain axis (MGB), which is composed of gut microbiota and its metabolites together with the central nervous system, neuroendocrine system, neuroimmune system and autonomic nervous system, is considered to be a bridge between environmental risk factors and pathological mechanisms of ADHD. Monoamine neurotransmitter levels and hypothalamic-pituitary-adrenal (HPA) axis disturbances, which have received much attention in ADHD research, are closely related to MGB imbalance. Given that the differences in geographical environment and dietary habits may cause regional differences in the intestinal microbial composition, exploring the influence of living habits on the specific characteristics and metabolites of intestinal microbes in different regions and their role in the pathological process of ADHD is helpful to understand the mechanism of MGB involving in ADHD and to provide a basis for accurate ADHD prevention and treatment strategies as well as life guidance.

Key words: attention deficit hyperactivity disorder, microbiota-gut-brain axis, pathogenesis, environmental factors, biomarkers

摘要: 肠道微生物群及其代谢产物与中枢神经系统、神经内分泌系统、神经免疫系统、自主神经系统等共同构成的微生物-肠-脑轴(MGB)被认为是环境危险因素参与注意缺陷多动障碍(ADHD)病理机制的桥梁,在ADHD研究中深受关注的单胺类神经递质水平及下丘脑-垂体-肾上腺轴(HPA轴)紊乱与MGB失衡密切相关。肠道微生物组成存在地域差异,探究生活习惯对不同地区患者肠道微生物种属特点和代谢产物的影响及其在病理过程中的作用,有助于理解MGB参与ADHD发病的机制,为制定精确的ADHD防治策略及生活指导提供依据。

关键词: 注意缺陷多动障碍, 微生物-肠-脑轴, 发病机制, 环境因素, 生物标志物

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