journal1 ›› 2012, Vol. 20 ›› Issue (12): 1077-1179.

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Relationship between serum neutrophil gelatinase-associated lipocalin and iron metabolic index in preschool children

CHEN Ke1,CHENG Xin-ran1,ZHANG Lan1,LUO Hong-yi1,GAO Ning1,WANG Jin1,FU Gui-ying1,MAO Meng2   

  1. 1 Department of Child Health Care and Child and Youth Growth and Development Treatment Center,Chengdu,Sichuan 610031,China;
    2 Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education,West China Second Hospital,Sichuan University,Chengdu,Sichuan 610081,China
  • Received:2012-04-09 Online:2012-12-06 Published:2012-12-06

学龄前儿童血清中性粒细胞明胶酶相关脂质运载蛋白与铁代谢指标相关性及其意义

陈科1,程昕然1,章岚1,罗红裔1,高宁1,王劲1,傅桂英1,毛萌2   

  1. 1 成都市妇女儿童中心医院儿童保健并儿童与青少年生长发育诊治中心,四川 成都 610031;
    2 四川大学华西第二医院教育部妇儿疾病与出生缺陷重点实验室,四川 成都 610081
  • 通讯作者: 毛萌,E-mail:dffmmao@126.com
  • 作者简介:陈科(1976-),男,四川人,主治医师,博士研究生,主要研究方向为儿童营养及儿童生长发育
  • 基金资助:
    瑞士SIGHT AND LIFE国际维生素A研究基金(20090221)

Abstract: 【Objective】 To explore the correlation of neutrophil gelatinase-associated lipocalin (NGAL) and iron metabolic index,including hemoglobin (HB),serum ferritin (SF),serum transferrin receptor (sTfR),transferritin receptor-ferritin index (TFR-F) and body iron content (BIC). 【Methods】 About 473 preschool children with 2~7 years old were randomly selected from eight kindergartens,including 223 boys and 250 girls with (47.8±14.5) months.HB was measured by HiCN method,NGAL,SF and sTfR by ELISA.TFR-F index and BIC were calculated according to the relevant index formula. 【Result】 There were significant correlation between NGAL and sTfR,TFR-F and BIC (the partial correlation coefficients were 0.23,0.24 and -0.15,P<0.01 or <0.05),respectively.The value of serum NGAL in anemic children was markedly higher than that of non-anemic children [(152.8±33.4) vs (220.7±25.4)pg/mL](P<0.05).Children with low sTfR level (cut by sTfR media value) had lower serum NGAL level than those with high sTfR level[(181.05±41.1) vs (257.6±47.8)pg/mL](P<0.05);however,children with low BIC level (cut by BIC media value) had higher serum NGAL level than those with high BIC level [(269.1±49.4) vs (181.3±30.8)pg/mL](P<0.05).The values of sTfR and TFR-F in children with low NGAL level (cut by NGAL media level) were significantly lower than those of children with high NGAL level (P<0.05),but not for HB,SF and BIC (P>0.05). 【Conclusion】 The impact of NGAL on iron metabolism may be mainly through the inhibition on erythroid proliferation,but no relationship with iron reserves process.

Key words: neutrophil gelatinase-associated lipocalin, iron metabolism, preschool children, anemia

摘要: 【目的】 初步分析中性粒细胞明胶酶相关脂质运载蛋白(neutrophil gelatinase-associated lipocalin,NGAL)水平对铁代谢指标血红蛋白(hemoglobin,HB)、铁蛋白(serum ferritin,SF)、血清转铁蛋白受体(serum transferrin receptor,sTfR)、转铁蛋白/铁蛋白指数(transferritin receptor-ferritin index,TFR-F)以及机体铁含量(body iron content,BIC)的关系。 【方法】 随机抽取473名3~6岁(不足7岁)学龄前儿童纳入本研究,利用氰化高铁血红蛋白法测定HB、ELISA法测定血清NGAL、SF及sTfR,并根据相关公式计算TRFI和BIC指数。 【结果】 血清NGAL与sTfR、TFR-F和BIC均呈显著相关关系(偏相关系数r=0.23、0.24、-0.15,P<0.01或<0.05)。贫血儿童血清NGAL水平显著低于非贫血儿童[(152.8±33.4)vs (220.7±25.4)pg/mL](P<0.05);以指标中位数为界,低sTfR组儿童血清NGAL水平明显低于高sTfR组[(181.05±41.1)vs(257.6±47.8)pg/mL](P<0.05),低BIC组儿童血清NGAL水平明显高于高BIC组[(269.1±49.4)vs(181.3±30.8)pg/mL](P<0.05)。低NGAL组儿童血清sTfR水平及TFR-F指数显著低于高NGAL组(P<0.05),而HB、SF以及BIC组间差异无统计学意义(P>0.05)。 【结论】 NGAL可能主要通过阻止红系统增殖参与调节儿童铁代谢稳态,而与机体铁储备过程无关。

关键词: 中性粒细胞明胶酶相关脂质运载蛋白, 铁代谢, 学龄前儿童, 贫血

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