journal1 ›› 2013, Vol. 21 ›› Issue (4): 342-344.

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Analysis of the curative effect of congenital hypothyroidism children.

JIANG Xue-jin1,WANG Xiao-rong2,WANG Jing2,GU Xue-zhu3,GAO Jing1,WANG You-jie1.   

  1. 1 Department of Maternal and Children Health Care,School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China;
    2 Institute of Maternal and Children Health,Suzhou,Jiangsu 215000,China;
    3 Municipal Hospital of Suzhou,Suzhou,Jiangsu 215000,China
  • Received:2012-09-04 Online:2013-04-06 Published:2013-04-06

先天性甲状腺功能低下症疗效评估及相关因素分析

姜雪锦1,王晓蓉2,王菁2,顾雪珠3,高静1,王友洁1   

  1. 1 华中科技大学同济医学院公共卫生学院儿少卫生与妇幼保健学系,湖北 武汉 430030;
    2 苏州市妇幼保健所,江苏 苏州 215000;
    3 苏州市立医院本部,江苏 苏州 215000
  • 通讯作者: 王菁,E-mail:sz_wj @hotmail.com
  • 作者简介:姜雪锦(1989-),女,山东人,在读硕士研究生,主要研究方向为儿少卫生与妇幼保健。
  • 基金资助:
    环保公益性行业科研专项(200909102)

Abstract: Objective To analyze the neural and psychological development of congenital hypothyroidism (CH) children from the newborn screening for CH,and provide evidences for estimating prognosis and exploring more perfect treatment. Method The DQ,motor,fine movement,adaption,language and social behavior of congenital hypothyroidism children were evaluated using neural and psychological development diagnosis scale for 0~6 years old children. Results Intelligence level of most CH children was in normal range,average scores of DQ were higher than 85 but in low-to-normal level in each age group.Neural and psychological development of CH children of different diagnosis age were not significantly different.The correlations between pretreatment FT3 and fine movement,adaption,language,social behavior were significant (P<0.05),and the correlation coefficients were -0.282,-0.280,-0.276,-0.192,respectively.The correlation between pretreatment FT4 and motor was significant (r=0.198,P<0.05). Conclusion Intelligence level of most CH children can achieve normal range.Both high FT3 level and low FT4 level can affect the neural and psychological developments of CH children.

Key words: congenital hypothyroidism, newborn screening, neural and psychological development

摘要: 目的 分析经新生儿疾病筛查程序诊治的甲状腺功能减低症(congenital hypothyroidism,CH)患儿的神经心理发育情况,为正确评估预后、探索更完善的治疗方案提供依据。方法 采用首都儿科研究所研制的0~6岁婴幼儿神经、心理发育诊断量表对CH患儿的发育商和大运动、精细动作、适应能力、语言、社交行为五大能区进行评价。结果 经新生儿疾病筛查程序诊治的CH患儿神经心理发育水平大部分处于正常水平,各年龄段的CH患儿平均发育商都在85分以上,但是接近正常范围的下限。不同诊断年龄对3岁以内患儿的神经心理发育影响差异无统计学意义。患儿确诊时FT3水平与精细动作、适应能力、语言、社交行为得分呈负相关(r值分别为-0.282、-0.280、-0.276、-0.192,P值均<0.05),患儿确诊时FT4水平与大运动得分呈正相关(r=0.198,P<0.05)。 结论 经新生儿疾病筛查程序诊治的CH患儿智能水平大部分可达到正常水平,确诊时FT3水平高和FT4水平低均可能影响患儿的神经心理发育。

关键词: 先天性甲状腺功能减低症, 新生儿疾病筛查, 神经心理发育

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