Abstract: Objective To detect the levels of resistin,adiponectin and leptin in the umbilical artery plasma of infants born to mothers with gestational diabetes,and preliminarily to study the factors of affecting fetal growth and development. Methods Thirty-three babies born to diabetic mothers were clinically selected as study group,another 30 normal full-term newborn as control group.Resistin,adiponectin and leptin levels in cord serum were measured for all of the subjects by enzyme-linked immunosorbent assay.The indicators of growth and development in study group were accurately measured.The results were analyzed by using SPSS16.0 software. Results Resistin and adiponectin content of cord serum in study group was lower than in the control group,the difference was statistically significant (P<0.001).Leptin level was higher than the control goup(P<0.001).Resistin content was negatively correlated with wegiht,ponderal Index and leptin (r=-0.673,-0.563,-0.412,P＜0.05),and positively correlated with adiponectin content (r=0.397,P=0.003). Conclusions There might be some relationship between resistin with adiponectin,leptin in umbilical artery plasma of infants with diabetic mothers,and resistin may be related to the regulation of fetal growth and development.

Key words: gestational diabetes, newborns, umbilical artery, adiponectin, leptin, resistin

摘要： 目的 测定糖尿病母儿脐血胰岛素抵抗素(以下简称抵抗素)、脂联素和瘦素含量，初步探讨妊娠期糖尿病母亲的胎儿生长发育的影响因素。方法 选取33例临床确诊的糖尿病母儿为研究组，另选30例正常足月新生儿为对照组，采用酶联免疫吸附法测定所有研究对象脐血抵抗素、脂联素及瘦素含量，精确测量糖尿病母儿生长发育指标，采用SPSS 16.0 软件进行结果分析。结果 研究组脐血抵抗素和脂联素含量低于对照组，差异有统计学意义(P<0.001)，瘦素高于对照组(P<0.001);糖尿病母儿脐血抵抗素与体重、Ponderal指数和瘦素均呈负相关(r=-0.673、-0.563 、-0.412，P均＜0.05)，与脂联素呈正相关(r=0.397，P=0.003)。结论 糖尿病母儿脐血抵抗素与脂联素和瘦素之间可能存在一定关联;抵抗素与糖尿病母儿宫内生长发育有关。

关键词: 抵抗素, 妊娠期糖尿病, 新生儿, 脐动脉, 脂联素, 瘦素