Abstract: Objective To observe the changes of 25 hydroxy vitamin D₃[25-(OH)D₃] concentration in the serum of children with asthma, and to analyse its relationship with the content of serum total immunoglobulin E(TIgE )and lung function index associated with asthma. Methods Serum 25-(OH )D₃, TIgE content and lung function index were tested in experimental group consisting of 42 patients suffered from asthma, and in control group consisting of 48 children with no asthma.Then comparisons were analyzed between the two groups. Results Compared with the normal control group, serum 25-(OH)D₃ level content in experimental group consisting of children with asthma was significantly decreased (P<0.01), but the serum TIgE content increased significantly (P<0.01);serum 25-(OH)D₃ level in experimental group composed of children with asthma was negatively correlated with TIgE (P<0.01), and positively correlated with forced expiratory small airway 25% flow (MEF25)and forced expiratory volume 50%(MEF50)(P<0.05). Conclusion Vitamin D deficiency is an important cause of asthma exacerbations in children, which may be related to inhibitory effect of 25-(OH)D₃ on the TIgE.

Key words: children asthma, 25-hydroxy vitamin D₃, total immunoglobulin E, pulmonary function

摘要： 目的 观察哮喘儿童血清25-羟维生素D₃[25-(OH)D₃]浓度变化, 分析其与哮喘有关的血清总免疫球蛋白E(TIgE)含量、肺功能指标的相关性。方法 检测42例哮喘组、48例正常对照组儿童血清25-(OH)D₃、TIgE含量, 以及肺功能指标, 并进行组间比较分析。结果 与正常对照组比较, 哮喘组儿童血清25-(OH)D₃含量明显下降(P＜0.01), 而血清TIgE含量则明显升高(P＜0.01);哮喘组儿童血清25-(OH)D₃与TIgE呈负相关(P＜0.01), 与小气道用力呼气25%流量(MEF25)、用力呼气50%流量(MEF50)呈正相关(P＜0.05)。结论 维生素D缺乏是导致儿童哮喘发作的重要原因之一, 可能与25-(OH)D₃对TIgE产生抑制作用有关。

关键词: 哮喘, 25-羟维生素D₃, 总免疫球蛋白E, 肺功能