Abstract: Objective To investigate macrosomia inflammatory indexes in vivo tumor necrosis factor-α (TNF-α) and high-sensitivity C-reactive protein (hs-CRP) level and the correlation. Methods As from January to December 2012, 30 cases of normal weight newborn babies and 60 cases of macrosomiain were Maternal and Child Health Care Hospital of Shaanxi investigated.According to the pregnant mother BMI, macrosomia were further divided into cases of mother obesity and cases of mother normal weight.3 mL neonatal umbilical cord blood was taken from baby.After the centrifugal, serum was taken out and hs-CRP and TNF-α were tested with enzyme-linked immunoassay. Results Levels of hs-CRP in every two groups were statistically significant (P<0.05), and gradually increased in normal newborns, huge children of normal weight mothers, huge child of obesity mothers three groups difference.TNF-α in the three groups showed no significant difference between the newborn (P>0.05).Birth weight and hs-CRP was positively correlated (r=0.417, P＜0.05).Birth weight and TNF-α was no significant correlation (P>0.05). Conclusion Macrosomia has low-grade inflammation, hs-CRP and birth weight has positively correlation.

Key words: macrosomia, tumor necrosis factor-α, high-sensitivity C-reactive protein

摘要： 目的 研究巨大胎儿体内炎性指标肿瘤坏死因子-α(tumor necrosis factor-α, TNF-α)及高敏C反应蛋白(high-sensitivity C-reactive protein, hs-CRP)的水平及相关性。方法 以2012年1-12月陕西省妇幼保健院出生的正常儿30例及巨大儿60例为研究对象。根据孕前母亲BMI, 将巨大儿进一步分为母亲肥胖的巨大儿及母亲体重正常的巨大儿。新生儿生后脐带结扎前采集脐带血3 mL离心, 取出血清, 酶联免疫法测hs-CRP及TNF-α。结果 hs-CRP在每两组间比较差异均有统计学意义(P＜0.05), 且在正常新生儿、母亲体重正常巨大儿、母亲肥胖巨大儿三组间呈逐渐升高趋势。TNF-α在三组间比较差异无统计学意义(P＞0.05)。出生体重与hs-CRP呈正相关, 相关系数r=0.417, P＜0.05。出生体重与TNF-α无明显相关性(P＞0.05)。结论 巨大胎儿体内存在低度炎症反应, hs-CRP与出生体重呈正相关。

关键词: 巨大儿, 肿瘤坏死因子-α, 高敏C反应蛋白