Abstract: Objective To investigate the effect of intrahepatic cholestasis of pregnancy(ICP) on pregnancy outcomes and neonates. Methods A total of 173 pregnant women who were diagnosed with ICP and delivered in gynecology department of Guizhou Provincial People's Hospital were classified as ICP group,and 180 healthy pregnant women were classified as control group from May 2013 to April 2017.Related indexs including maternal age,gravidity,parity,delivery mode,pregnancy outcomes and the neonatal laboratory indexes and diseases were collected and compared between the two groups. Results There was no significant difference on maternal age and times of pregnancy between the two groups,but the times of gravidity and the proportions of cesarean section in ICP group were significantly higher than those in control group (P<0.05);The proportions of low birth weight infants,meconium stained amniotic fluid,and asphyxia in ICP group were significantly higher than those in control group (P<0.05);The levels of TC,ALP and TBA in ICP group were significantly higher than those in control group (P<0.05). Conclusion ICP can cause neonatal birth and postpartum abnormalities,such as low birth weight infants,meconium stained amniotic fluid,asphyxia,and neonatal ALP,TBA abnormalities.

Key words: intrahepatic cholestasis of pregnancy, pregnancy outcome, neonatal diseases

摘要： 目的 探讨妊娠期肝内胆汁淤积症(ICP)对妊娠结局及新生儿的影响。方法 选取2013年5月-2017年4月本院妇产科诊治并分娩的ICP孕妇173例为ICP组,180例健康孕妇作为对照组,收集两组孕妇的年龄、孕次、产次,流产、早产、低出生体重儿、宫内窘迫、窒息等妊娠结局,新生儿血常规、凝血机制、肝功能等相关实验室指标及疾病情况,比较两组妊娠结局及新生儿实验室指标及疾病的差异。结果 两组孕妇间年龄、孕次之间差异无统计学意义(P>0.05),但ICP组的产次、剖宫产数明显要高于对照组(P＜0.05);两组新生儿出生时及出生后情况比较显示:ICP组低出生体重儿、羊水粪染、窒息、心肌损害的比例明显高于对照组(P<0.05);ICP组间新生儿总胆固醇(TC)、总胆汁酸(TBA)、碱性磷酸酶(ALP)明显高于对照组,差异有统计学意义(P<0.05)。结论 ICP可引起新生儿产时及产后异常,出现低出生体重儿、羊水粪染、窒息及新生儿ALP、TBA等实验室指标异常。

关键词: 妊娠期胆汁淤积综合征, 妊娠结局, 新生儿疾病