Research progress of executive function in children with iron deficiency

doi:10.11852/zgetbjzz2017-25-04-12

Abstract

Abstract: Iron deficiency (ID) or iron deficiency anemia (IDA) is the most commom form of nutrient deficiency worldwide.It's highly prevalent in pregnant women and infants.Early ID affects brain metabolism,neurotransmitters and myelination.Consequently,it affects nerve cognitive function and behavior such as working memory,inhibitory control and cognitive flexibility that is the main component of executive function.Executive function is senior congitive function and develops quickly to top in children born after 1~2 years,there may be an iron-dependent crucial period.To understand the development of children's executive function and find out the most important development window will benefit public health prevention strategies of early iron deficiency.

Key words: iron deficiency, cognitive function, executive function

摘要： 铁缺乏(iron deficiency,ID)和缺铁性贫血(iron deficiency anemia,IDA)是全球一种常见的单一营养缺乏症,尤其多见于孕妇及婴幼儿。早期缺铁通过影响大脑神经代谢、神经递质及髓鞘化而影响儿童的神经认知功能和行为,包括以工作记忆、抑制性控制、认知灵活度为主要成分的执行功能的发展。执行功能是高级认知功能,其发展在儿童出生后1~2年时达高峰,可能存在着铁依赖的发育关键期。了解儿童执行功能的发展,并弄清其铁依赖的发育关键期,对制定早期预防铁缺乏的公共卫生策略具有重要的意义。

关键词: 铁缺乏, 认知功能, 执行功能

CLC Number:

R179

ZHU Liu-yan,SHAO Jie. Research progress of executive function in children with iron deficiency[J]. journal1, 2017, 25(4): 365-368.

朱柳燕,邵洁. 铁缺乏与儿童执行功能的研究进展[J]. 中国儿童保健杂志, 2017, 25(4): 365-368.

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URL: https://manu41.magtech.com.cn/Jwk_zgetbjzz/EN/10.11852/zgetbjzz2017-25-04-12

https://manu41.magtech.com.cn/Jwk_zgetbjzz/EN/Y2017/V25/I4/365

References

[1] Lozoff B,Georgieff MK.Iron deficiency and brain developme[J].Semin Pediatr Neurol,2006,13(3):158-165.
[2] Adele Diamond.Executive Functions[J].Annu Rev Psychol,2013,64:135-68
[3] 邵洁.早期缺铁与大脑发育[J].中国儿童保健杂志,2014,23(2):116-118.
[4] Estrada JA,Contreras I,Pliego-Rivero FB,et al.Molecular mechanisms of cognitive impairment in iron deficiency:alterations in brain-derived neurotrophic factor and insulin-like growth factor expression and function in the central nervous system[J].Nutr Neurosci,2014,17(5):193-200.
[5] Tran PV,Fretham SJB,Wobken J,et al.Gestational-neonatal iron deficiency suppresses and iron treatment reactivates IGF signaling in developing rat hippocampus[J].Am J Physiol-Endoc M,2012,302(3):E316-E324.
[6] Lou J,Mai X,Lozoff B,et al.Prenatal iron deficiency and auditory brainstem responses at 3 and 10 months:a pilot study.HKJ Pediatr,2016,20(2):71-79.
[7] Lee DL,Strathmann FG,Gelein R,et al."Iron deficiency disrupts axon maturation of the developing auditory nerve"[J].J Neurosci,2012.32(14):5010-5015.
[8] Erikson KM,Jines BC,Hess EJ,et al,Iron deficiency decreases dopamine D1 and D2 receptors in rat brain[J].Pharmacol Biochem Behav,2001,69:409-418.
[9] Yuan Li,Jonghan Kim,Peter D,et al.Severe postnatal iron deciency alters emotional behavior and dopamine levels in the prefrontal cortex of young male rats[J].The Journal of Nutrition,2011,141:2133-2138.
[10] Rona RR.Molecular aspects of monoamine oxidase B[J].Progress in Neuro-Psychopharmacology & Biological Psychiatry,2016,69:81-89.
[11] Golub MS,Hogrefe CE.Fetal iron deficiency and genotype influence emotionality in infant rhesus monkeys[J].Journal of Nutrilion,2015,145(3):647-653.
[12] Golub M,Hogrefe C.Prenatal iron deficiency and monoamine oxidase A (MAOA) polymorphisms:combined risk for later cognitive performance in rhesus monkeys[J].Genes Nutr,2014,9:381.
[13] Bressan RA,Crippa JA.The role of dopamine in reward and pleasure behaviour:review of data from preclinical research[J].Acta Psychiatr Scand,2005,Suppl:14-21.
[14] Erica L,Unger B,Laura E,et al.Low brain iron effects and reversibility on striatal dopamine dynamics[J].Experimental Neurology,2014,261:462-468.
[15] Schmidt AT,Ladwig EK,Wobken JD,et al.Delayed alternation performance in rats following recovery from early iron deficiency[J].Physiol Behav,2010,101(4):503-508
[16] Schmidt AT,Alvarez GC,Grove WM,et al.Early iron deficiency enhances stimulus-response learning of adult rats in the context of competing spatial information[J].Dev Cogn Neurosci,2012,2(1):174-180.
[17] de Deungria M,Rao R,Wobken JD,et al.Perinatal iron deficiency decreases cytochrome c oxidase (CytOx) activity in selected regions of neonatal rat brain[J].Pediatr Res,2000,48(2):169-176.
[18] Carlson ES,Fretham SJ,Unger E,et al.Hippocampus specific iron deficiency alters competition and cooperation between developing memory systems[J].J Neurodevelop Disord,2010,2:133-143.
[19] Leyshon BJ,Radlowski EC,Mudd AT,et al.Postnatal iron deficiency alters brain development in piglets[J].J Nutr,2016,146(7):1420-1427.
[20] Lozoff B.Early iron deficiency has brain and behavior effects consistent with dopaminergic dysfunction[J].J Nutr,2011,141(Suppl 4):740-746.
[21] Carter RC,Jacobson JL,Burden MJ,et al.Iron deficiency anemia and cognitive function in infancy[J].Pediatrics,2010,126(2):427-434.
[22] Tran TD,Biggs BA,Tran T,et al.Impact on infants' cognitive development of antenatal exposure to iron deficiency disorder and common mental disorders[J].Plos One,2013,8(9):e74876.
[23] Algarin C,Nelson CA,Lozoff B,et al.Iron-deficiency anemia in infancy and poorer cognitive inhibitory control at age 10 years[J].Dev Med Child Neurol,2013,55:453-458.
[24] Lozoff B,Jimenez E,Smith JB.Double burden of iron deficiency in infancy and lowsocioeconomic status:a longitudinal analysis of cognitive test scores to age 19 years[J].Arch Pediatr Adolesc Med,2006,160(11):1108-1113.
[25] Lozoff B,Smith JB,Kaciroti N,et al.Functional significance of early-life iron deficiency:outcomes at 25 years[J].J Pediatr,2013,163(5):1260-1266.
[26] Murray-Kolb LE.Iron and brain functions[J].Curr Opin Clin Nutr Metab Care,2013,16(6):703-707.
[27] Umamaheswari K,Bhaskaran M,Krishnamurthy G,et al.Effect of iron and zinc deficiency on short term memory in children[J].Indian Pediatr,2011,48(4):289-293.
[28] Demanet J,Liefooghe B,Verbruggen F.Valence,arousal,and cognitive control:a voluntary task-switching study[J].Front Psychol,2011,2:336.