Research progress on vitamin A in breast milk

doi:10.11852/zgetbjzz2019-0106

journal1 ›› 2019, Vol. 27 ›› Issue (11): 1204-1207.DOI: 10.11852/zgetbjzz2019-0106

Previous Articles Next Articles

Research progress on vitamin A in breast milk

DENG Jing, LI Ting-yu

Department of Child Health Care,Children′s Hospital of Chongqing Medical University; Ministry of Education Key Laboratory of Child Development and Disorders; National Clinical Research Center for Child Health and Disorders; China International Science and Technology Cooperation base of Child development and Critical Disorders; Children′s Hospital of Chongqing Medical University, Chongqing, P.R China.Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders; Chongqing Key Laboratory of Child Health and Nutrition,Chongqing 400014,China

Received:2019-01-21 Online:2019-11-10 Published:2019-11-10
Contact: LI Ting-yu,E-mail:tyli@vip.sina.com

母乳中维生素A的研究进展

邓晶综述 , 李廷玉审校

重庆医科大学附属儿童医院儿童保健科, 儿童发育疾病研究教育部重点实验室; 国家儿童健康与疾病临床医学研究中心, 儿童发育重大疾病国家国际科技合作基地,认知发育与学习记忆障碍转化医学重庆市重点实验室,儿童营养与健康重庆市重点实验室, 重庆 400014

通讯作者: 李廷玉,E-mail:tyli@vip.Sina.com
作者简介:邓晶(1994-),女,重庆人,住院医师,硕士研究生,主要研究方向为儿童营养。
基金资助:
国家自然科学基金(NSFC)面上项目(81771223)

Abstract

Abstract: Vitamin A (VA) is an essential micronutrient,which plays an important role in epithelial integrity,visual development,immunity,reproductive function,growth and development as well as brain development.Although the public health policy of supplementing VA has been widely implemented,vitamin A deficiency (VAD) remains a significant public health concern in developing countries worldwide.For exclusively breastfed infants,breast milk is the only source of VA intake.However,there are currently some controversies about the level of VA in breast milk,whether it meets the needs of infants,and how to supplement vitamin AD in clinic.Therefore,it is important to know the level of VA in breast milk,the factors affecting VA level in breast milk and the reasonable supplementary dose of VA.To this end,this paper reviews the research progress on VA research in breast milk.

Key words: breastmilk, vitaminA, essentialmicronutrient

摘要： 维生素A(VA)是人体必需的微量营养素,在维持上皮完整、视觉发育、免疫、生殖功能、生长发育、脑发育等方面均有重要作用。尽管补充VA的公共卫生政策已经广泛推行,但维生素A缺乏(VAD)仍是全球发展中国家的重要公共卫生问题。对于纯母乳喂养的婴儿,母乳是其VA的唯一营养来源,母乳中VA水平究竟如何,是否满足婴儿需要,临床上如何补充维生素AD制剂等均存在一些争议,所以了解母乳VA水平、影响母乳中VA水平的因素以及VA的合理补充剂量很重要。为此,本文就母乳中VA的研究进展进行综述。

关键词: 母乳, 维生素A, 必需微量营养素

CLC Number:

R174.4

DENG Jing, LI Ting-yu. Research progress on vitamin A in breast milk[J]. journal1, 2019, 27(11): 1204-1207.

邓晶 , 李廷玉. 母乳中维生素A的研究进展[J]. 中国儿童保健杂志, 2019, 27(11): 1204-1207.

References

[1] 李梦月,殷刚柱.婴儿期母乳喂养的研究进展[J].中国医药指南,2014,12(4):49-50.
[2] 毛萌,李廷玉.儿童保健学[M].北京:人民卫生出版社,2014:168-170.
[3] Tanumihardjo SA,Russell RM,Stephensen CB,et al.Biomarkers of Nutrition for Development (BOND)-Vitamin A Review[J].J Nutr,2016,146(Suppl 9):1816-1848.
[4] Parigi SM,Maria E,Pia L,et al.Breast milk and solid food shaping intestinal immunity[J].Front Immuno,2015,6:415.
[5] Veronica LT,Ana LM,Humberto AG,et al.Dose-to-mother′ deuterium oxide dilution technique:an accurate strategy to measure vitamin a intake in breastfed infants[J].Nutrients,2017,9(2):169.
[6] Dror DK,Allen LH .Retinol-to-fat ratio and retinol concentration in human milk show similar time trends and associations with maternal factors at the population level:a systematic review and meta-analysis[J].Adv Nutr,2018,9(Suppl 1):332-346.
[7] Engle-Stone R,Haskell MJ,Nankap M,et al.Breast milk retinol and plasma retinol-binding protein concentrations provide similar estimates of vitamin A deficiency prevalence and identify similar risk groups among women in Cameroon but breast milk retinol underestimates the prevalence of deficiency among young children[J].J Nutr,2014,144(2):209-217.
[8] Deminice TMM,Ferraz IS,Monteiro JP,et al.Vitamin A intake of Brazilian mothers and retinol concentrations in maternal blood,human milk,and the umbilical cord[J].J Int Med Res,2018,46(4):1555-1569.
[9] 陈龙.我国婴幼儿配方食品标准中维生素适宜含量值评价[D].合肥:安徽医科大学,2018:1-97.
[10] 中国营养学会.中国居民膳食营养素参考摄入量(2013版) [M].北京:科学出版社,2014:322-323.
[11] De Benoist B,Martines JE,Goodman T.Vitamin A supplementation and the control of vitamin A deficiency:conclusions[J].Food Nutr Bull,2015,22(3):335-337.
[12] 刘静.呼和浩特市母乳中维生素含量的研究[J].食品研究与开发,2016,37(16):20-22.
[13] 方芳,李婷,李艳杰,等.呼和浩特地区母乳中脂溶性VA、VD、VE含量[J].乳业科学与技术,2014,37(3):5-7.
[14] 郭艳红,苏米亚,刘翠平,等.中国乳母膳食营养研究现状[J].乳业科学与技术,2015,38(2):20-22.
[15] 杨春.中国人群维生素A的影响因素[J].医学综述,2016,22(7):1249-1252.
[16] Jasmijn YDV,Shikha P,Elizabeth M,et al.Maternal circulating vitamin status and colostrum vitamin composition in healthy lactating women-a systematic approach[J].Nutrients,2018,10(6):687.
[17] Green MH,Green JB,Akohoue SA,et al.Vitamin A intake affects the contribution of chylomicrons vs.retinol-binding protein to milk vitamin A in lactating rats[J].J Nutr,2001,131(4):1279-1282.
[18] Neves PAR, Saunders C,Barros DCD,et al.Vitamin A supplementation in Brazilian pregnant and postpartum women:a systematic review[J].Rev Bras Epidemiol,2015,18(4):824-836.
[19] Tomiya MTO,de Arruda IKG,Da Silva Diniz A,et al.The effect of vitamin A supplementation with 400 000 IU vs 200 000 IU on retinol concentrations in the breast milk:a randomized clinical trial[J].Clinl Nutr,2017,36(1):100-106.
[20] Ross AC,Pasatiempo AM,Green MH.Chylomicron margination,lipolysis,and vitamin a uptake in the lactating rat mammary gland:implications for milk retinoid content[J].Exp Biol Med (Maywood),2004,229(1):46-55.
[21] WHO.Global prevalence of vitamin A deficiency in populations at risk 1995-2005[R].Geneva:WHO,2009.
[22] McCauley ME,van denBroek N,Dou L,et al.Vitamin A supplementation during pregnancy for maternal and newborn outcomes[J].Cochrane Database Syst Rev,2015(10):D8666.
[23] Souza G,Dolinsky M,Matos A,et al.Vitamin A concentration in human milk and its relationship with liver reserve formation and compliance with the recommended daily intake of vitamin A in pre-term and term infants in exclusive breastfeeding[J].Arch Gynecol Obstet,2015,291(2):319-325.
[24] Reyna S,Hugo MR,Rosa H,et al.Retinol and α-tocopherol in the breast milk of women after a high-risk pregnancy[J].Nutrients,2017,9(1):1pii:E14.
[25] Alam DS,Raaij JMAV,Hautvast JGAJ,et al.Effect of dietary fat supplementation during late pregnancy and first six months of lactation on maternal and infant vitamin A status in rural Bangladesh[J].J Health Popul Nutr,2010,28(4):333-342.
[26] Frano MRL,Woodhouse LR,Burnett DJ,et al.Biofortified cassava increases β-carotene and vitamin A concentrations in the TAG-rich plasma layer of American women.[J].Br J Nutr,2013,110(2):310-320.
[27] Bechoff,Aurélie,Dhuique-Mayer C .Factors influencing micronutrient bioavailability in biofortified crops[J].Ann N Y Acad Sci,2017,1390(1):74-87.
[28] Yang C,Chen J,Liu Z,et al.Prevalence and influence factors of vitamin A deficiency of Chinese pregnant women[J].Nutr J,2015,15(1):12.
[29] 张艳秋.乳母膳食状况与母乳营养素含量及婴儿生长发育水平的前瞻性观察[D].济南:山东大学,2016:1-50.
[30] 黄志.269例乳母膳食营养状况及乳汁中矿物质含量的研究[D].长沙:中南大学,2014:1-70.
[31] 苏宜香.孕妇乳母膳食指南食物推荐摄入量解读[J].临床儿科杂志,2018,36(8):645-648.
[32] Papich MG.Vitamin A[M]//Papich MG.Saunders handbook of veterinary drugs (Fourth Edition).St.Louis:W.B.Saunders,2016:841-842.
[33] Oliveira JM,Allert R,East CE.Vitamin A supplementation for postpartum women[J].Cochrane Db Syst Rev,2016,3:D5944.
[34] WHO.Guideline:vitamin A supplementation in postpartumwomen[R].Geneva WHO,2011.
[35] 苏宜香.《中国居民膳食营养素参考摄入量,2013版》儿童相关DRIs修订要点解读[J].中国儿童保健杂志,2015,23(7):673-675.
[36] WHO.Guideline:vitamin A supplementation in infants 1~5 months of age[R].Geneva:WHO,2011.
[37] WHO.Guideline:vitamin A supplementation in infants and children 6~59 months of Age[R].Geneva:WHO,2011.
[38] Imdad A,Mayo-Wilson E,Herzer K,et al.Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age[J].Cochrane Db Syst Rev,2017,3:D8524.

Research progress on vitamin A in breast milk

母乳中维生素A的研究进展

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 2

Recommended Articles

Metrics

[1]	ZHANG Xu-guang, CHEN Yan-ping, CHEN Dong-kai, ZHANG Dong-mei, LIU Li, JING Hong, HOU Shao-ying. Cross-sectional study on serum vitamin A level in children aged 0 to 16 years in different ages [J]. journal1, 2019, 27(11): 1215-1218.
[2]	ZHANG Yuan,LIANG Guan-yu,LIU Na,WU Jiao-jiao,CUI Yu-gui,LIU Jia-yin,QIN Rui. Cross-sectional investigation of knowledge-attitude-behavior model into breastmilk storage in Nanjing [J]. journal1, 2015, 23(3): 326-327.