Abstract: Objective To explore the research hotspots and development trends of neonatal hypoxic-ischemic brain damage (HIBD) at home and abroad, so as to provide reference and guidance for further research in the later stage. Methods Literature published till February 31st 2019 was searched from PubMed, Web of Science, FMRS, CNKI, WanFang and WeiPu database, and the basic methods of bibliometrics were used.Data were analyzed from the number of countries, subject distribution, journals and authors, institutions and funds, high frequency key words.A co-word matrix for high-frequency keywords was established and then cluster analysis was performed. Results 1)A total of 5 594 articles published in 1 246 journals were selected, including 205 journals with influential factors over 5. 2) The top three countries in terms of article volume on neonatal HIBD were the United States, China and Japan.3) The United States has formed a core group of authors in the field of neonatal HIBD, with high-quality journals, playing an irreplaceable role in this field.However, the core force of research on neonatal HIBD has not been formed in China.4) Eight of the top 10 research institutions in China were from advanced institutions, and the most research institutions were from Zhengzhou University, while the more in-depth researches were in Shanghai. Conclusions At present, China plays a leading role in the researches on neonatal HIBD.Multi-disciplinary, multi-level and multiregional large samples researches in this field are warranted in order to better promote clinical research.It is an urgent task to develop new drugs and targets for neonatal hypoxic-ischemic therapy, and the exploration of the role of autophagy in HIBD and related mechanisms may provide new ideas.

Key words: hypoxic-ischemic brain damage, neonates, bibliometric

摘要： 目的 分析国内外新生儿缺氧缺血性脑损伤的研究热点和发展趋势, 为后期开展深入研究提供借鉴和指导。方法 运用文献计量学分析方法, 以建库至2019年12月31日PubMed 、Web of Science 、FMRS、中国知网、万方数据库、维普数据库收录文献为研究对象, 从发文量的国家、学科分布、发文期刊及作者、机构及基金、高频关键词5个方面统计分析, 并构建高频关键词共词矩阵然后进行聚类分析。结果 1)共筛选出5 594篇文献, 分别发表于1 246种期刊, 其中影响因子超过5的期刊205种。2)发文量前3的国家依次是美国、中国和日本。3)美国在新生儿缺氧缺血性脑损伤领域已经形成核心作者群, 拥有高质量期刊, 具有举足轻重的作用, 主导该领域研究。我国尚未形成新生儿缺氧缺血性脑损伤研究的核心力量。4)国内发文量居前10的研究机构有8所来自于高等院校, 研究最多的机构来源于郑州大学, 而研究更深入的分布于上海。结论 我国目前对于新生儿缺氧缺血性脑损伤的研究仍处于领先地位, 该领域的研究仍需进行多学科、多层次、多地区大样本的分析, 以更好地促进临床研究。开发用于新生儿缺氧缺血性治疗的新药物、新靶点是一项亟待解决的工作, 而自噬在HIBD中的作用及相关机制的探索或将可以提供新的思路。

关键词: 缺氧缺血性脑损伤, 新生儿, 文献计量