journal1 ›› 2021, Vol. 29 ›› Issue (3): 285-288.DOI: 10.11852/zgetbjzz2020-0213

• Review • Previous Articles     Next Articles

Research progress on the preventive application of glutamine in necrotizing enterocolitis in premature infants

ZHANG Hai-jian, ZHU Ming-zhe   

  1. Department of Pediatrics,Binzhou Medical University hospital,Yantai,Shandong 264100,China
  • Received:2020-02-21 Revised:2020-03-23 Online:2021-03-10 Published:2021-03-10
  • Contact: ZHU Ming-zhe,


张海建 综述, 朱明哲 审校   

  1. 滨州医学院烟台附属医院儿科,山东 烟台 264100
  • 通讯作者: 朱明哲,
  • 作者简介:张海建(1993-),男,山东人,硕士研究生,主要研究方向为儿童保健。

Abstract: Necrotizing enterocolitis (NEC) is one of the most common acute and fatal gastrointestinal emergencies in premature infants,mainly manifested as abdominal distension,hematochetia,etc.In severe cases,intestinal perforation and even septicemia may occur.The etiology and pathogenesis is unclear,some studies have found that intestinal mucosa barrier damage may be related to its pathogenesis,glutamine (Gln),the essential amino acid for human body,plays an irreplaceable role in maintaining intestinal mucosal integrity and reducing intestinal mucosal damage and ischemic necrosis.This paper reviews the preventive application of glutamine in NEC in premature infants.

Key words: glutamine, necrotizing enterocolitis, premature infants

摘要: 坏死性小肠结肠炎(NEC)是早产儿最常见的急性和致死性消化道急症之一,其主要表现为腹胀、便血等,严重者可出现肠穿孔甚至败血症。目前,NEC的病因及发病机制尚未明确,有研究发现肠黏膜屏障损害可能与其发病有关,谷氨酰胺(Gln)作为人体所需的条件必需氨基酸,在维持肠黏膜完整性,减少肠黏膜受损、缺血坏死中具有不可替代的作用,本文就谷氨酰胺在早产儿坏死性小肠结肠炎的预防性应用作一综述。

关键词: 谷氨酰胺, 坏死性小肠结肠炎, 早产儿

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