doi:10.11852/zgetbjzz2014-22-04-15

Abstract

摘要： 与周围神经系统相比, 中枢神经系统损伤后的再生能力很弱, 其主要原因是神经元与轴突在修复过程中促进性环境的缺如和抑制性环境的存在。配对免疫球蛋白样受体B(paired immuonglobin-like receptor B, Pir-B)是近年来新发现的继神经生长抑制因子的受体NgR之后三种髓鞘抑制分子Nogo、OMpg、MAG的另一种共同受体, 且众多体外研究和动物实验研究发现, 同时封闭NgR和Pir-B, 几乎可以完全消除髓鞘相关抑制分子对轴突再生的阻碍作用。本文就Pir-B抑制受损神经再生的作用机制及所致相关神经系统疾病展开相关综述。

关键词: 配对免疫球蛋白样受体B, 神经生长抑制因子受体, 髓鞘抑制分子, 轴突再生

CLC Number:

R725

卢祖琳, 李芳, 刘敬. 配对免疫球蛋白样受体B与神经轴突再生障碍[J]. 中国儿童保健杂志, 2014, 22(4): 387-389.

0
/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://manu41.magtech.com.cn/Jwk_zgetbjzz/EN/10.11852/zgetbjzz2014-22-04-15

https://manu41.magtech.com.cn/Jwk_zgetbjzz/EN/Y2014/V22/I4/387

References

[1] Rauschecker M, Stratakis CA.Molecular generics of adrenocortical tumor formation and potential pharmacologic targets[J].Minerva Endocrinol, 2012, 37(2):133-139.
[2] Brown JA, Diggs-Andrews KA, Gianino SM, et al.Neurofibromatosis-1 heterozygosity impairs CNS neuronal morphology in a cAMP/PKA/ROCK-dependent manner[J].Molecular and Cellular Neurosciences, 2012, 49(1):13-22.
[3] Cao Z, Gao Y, Deng K, et al.Receptors for myelin inhibitors:Structures and therapeutic opportunities[J].Molecular and Cellular Neuroscience, 2010, 43:1-14.
[4] Adelson JD, Barreto GE, Xu L, et al.Neuroprotection from stroke in the absence of MHCI or PirB[J].Neuron, 2012, 73:1100-1107.
[5] Kubagawa H, Burrows PD, Cooper MD.A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells[J].Proceedings of the Nationals Academy of Sciences of the United States of America, 1997, 94(10):5261-5266.
[6] Takai T.Paired immunoglobulin-like receptors and their MHC class I recognition[J].Immunology, 2005, 115(4):433-440.
[7] Syken J, Grandpre T, Kanold PO, et al.Pir-B restricts ocular-dominance plasticity in visual cortex[J].Science, 2006, 313(5794):1795-1800.
[8] Atwal JK, Pinkston-Gosse J, Syken J, et al.PirB is a functional receptor for myelin inhibitors of axonal regeneration[J].Science, 2008, 322(5903):967-970.
[9] Takai T, Ono M.Activating and inhibitory nature of the murine paired immunoglobulin-like receptor family[J].Lmmunological Reviews, 2001, 181:215-222.
[10] 王华, 熊英, 母得志.配对免疫球蛋白B抑制新生大鼠缺氧缺血损伤神经细胞再生的研究[J].中国新生儿科杂志, 2012, 27(4):269-273.
[11] Gou X, Zhang Q, Xu N, et al.Spatio-temporal expression of paired immunoglobulin-like receptor-B in the adult mouse brain after focal cerebral ischaemia[J].Brain Inj, 2013, 27(11):1311-1315.
[12] Deng XH, Al WM, Lel DL, et al.Lipopolysaccharide induce paired immunoglobulin-like receptor B (PirB) expression, synaptic alteration, and learning-memory deficit in rats[J].Neuroscience, 2012, 209:161-170.
[13] Zhou Y, Qiao R, Rao J, et al.Expression of PirB in normal and injured spinal cord of rats[J].J Huazhong Univ Sci Technol[Med Sci], 2010, 30(4):482-485.
[14] Kim T, Vidal GS, Djurisic M, et al.Human LilrB2 Is a β-Amyloid receptor and its murine homoloy PirB regulates synaptic plasticity in an Alzheimer's model[J].Science, 2013, 341:1399-1404.
[15] VanGuilder Starkey HD, Van Kirk CA, Bixler GV, et al.Neuroglial Expression of the MHCI pathway and PirB receptor is upregulated in the hippocampus with advanced aging[J].J Mol Neurosci, 2012, 48(1):111-126.
[16] Wang F, Cui H, Su Y, et al.Expression change of PirB in mice retina after optic nerve injury[J].Molecular Medicine Reports, 2010, 3(3):405-407.
[17] Cai XF, Yuan R, Hu Z, et al.Expression of PirB protein in intact and injured optic nerve and retina of mice[J].Neurochemical Research, 2012, 37(3):647-654.
[18] Fujita Y, Endo S, Takai T, et al.Myelin suppresses axon regeneration by PIR-B/SHP-mediated inhibition of Trk activity[J].EMBO J, 2011, 30(7):1389-1401.
[19] Thams S, Oliveira A, Cullheim S.MHC class I expression and synaptic plasticity after nerve lesion[J].Brain Research Reviews, 2008, 57(1):265-269.
[20] Jaimie DA, George EB, Xu L, et al.Neuroprotection from stroke in the absence of MHC I or PirB[J].Neuron, 2012, 73(6):1100-1107.
[21] Wang H, Xiong Y, Mu D.PirB restricts neuronal regeneration in developing rat brain following hypoxia-ischemia[J].Molecular Medicine Reports, 2012, 6(2):339-344.
[22] Raiker SJ, Lee H, Baldwin KT, et al.Oligodendrocytemyelin glycoprotein and Nogo negatively regulate activity-dependent synaptic plasticity[J].Journal of Neuroscience, 2010, 30(37):12432-12445.
[23] Fujita Y, Takashimal R, Endo S, et al.The p75 receptor mediates axon growth inhibition through an association with Pir-B[J].Cell Death Dis, 2011, 2:198-202.
[24] Lee JK, Geoffroy CG, Chan AF, et al.Assessing spinal axon regeneration and sprouting in Nogo-, MAG-, and OMgp-deficient mice[J].Neuron, 2010, 66(5):663-670.

配对免疫球蛋白样受体B与神经轴突再生障碍

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

[1]	LIU Haodong, LI Cheng, ZHAO Min, XI Bo. Association of abdominal obesity and pre-abdominal obesity with hyperuricemia in children [J]. Chinese Journal of Child Health Care, 2023, 31(7): 707-712.
[2]	YE Zhixu, YU Fuxun. Research progress of gut microbiota and respiratory virus infection in children [J]. Chinese Journal of Child Health Care, 2023, 31(7): 766-769.
[3]	ZHU Lijun, LI Biaozhang, ZHOU Jiawen, WU Baixin, LI Weidong. Disease burden of low body weight in children under 5 years old in China from 1990 to 2019 [J]. Chinese Journal of Child Health Care, 2023, 31(7): 790-793.
[4]	. [J]. Chinese Journal of Child Health Care, 2023, 31(5): 576-580.
[5]	WU Qiaoling, XU Jian, ZHAO Zhengyan, PENG Yongmei, GONG Chundan. Correlation of hypersensitive C-reactive protein and metabolic syndrome in children and adolescents [J]. Chinese Journal of Child Health Care, 2023, 31(4): 427-432.
[6]	LI Yu, ZHAO Jia-hong, KAN Xuan. Clinical application of China Children′s Asthma Action Plan [J]. Chinese Journal of Child Health Care, 2023, 31(2): 185-189.
[7]	WANG Xu, WANG Shu-ying, LI Li, ZOU Ying-xue. Meta-analysis of the risk factors for recurrent wheezing after bronchiolitis [J]. Chinese Journal of Child Health Care, 2023, 31(2): 190-194.
[8]	. [J]. Chinese Journal of Child Health Care, 2023, 31(2): 229-232.
[9]	CAI Dong, ZHOU Li-xia, XU Hua-fen. The effects of MiR-223-3p on the inflammatory response and cell damage in the intestinal tissue of neonatal rats with necrotizing enterocolitis by targeting NLRP3 [J]. Chinese Journal of Child Health Care, 2023, 31(1): 46-51.
[10]	ZHONG Yao-yao, ZHANG Li-qin, LI Shuo, JI Yong-juan, LI Jun-xin. Case report and literature review of PUF60 gene de novo mutation related Verheij syndrome [J]. Chinese Journal of Child Health Care, 2023, 31(1): 113-116.
[11]	LI Yu, KAN Xuan. Research progress in the application of bacterial lysates in children with respiratory allergic diseases [J]. Chinese Journal of Child Health Care, 2022, 30(12): 1336-1340.
[12]	ZHANG Yang, WANG Hui-yuan, GENG Yan, JIN Qiao-yan, HAO Juan-juan, HOU Wei. Status quo and related factors of emotional problems in children with bronchial asthma [J]. Chinese Journal of Child Health Care, 2022, 30(12): 1400-1403.
[13]	. [J]. Chinese Journal of Child Health Care, 2022, 30(12): 1414-1416.
[14]	YANG Li-juan, DENG Gao, DING Bo, YANG Li-min, LI Dong-ming, HUANG Yong-fang, LIN Na. Association of ADAM33 gene and its serum level with the risk of asthma in Zhuang children in Guangxi [J]. Chinese Journal of Child Health Care, 2022, 30(11): 1185-1190.
[15]	LI Wan-ying, SONG Chun-lan, SHAN Zhao-qian, XIONG Lei-lei, ZHANG Zhi-ying. Changes and significance of cardiovascular metabolic indicators in children with asthma at different control levels [J]. Chinese Journal of Child Health Care, 2022, 30(11): 1246-1249.