journal1 ›› 2014, Vol. 22 ›› Issue (12): 1239-1241.DOI: 10.11852/zgetbjzz2014-22-12-03

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Assessment the motor developmental outcome at 4 years old of children conceived by intracytoplasmic sperm injection.

HONG Qin1,CHI Xia1,2,YANG Lei1,ZHANG Min1,LIU Xiao1,ZHANG Lei1,WU Lan1,XIE Ya-chun1,DOU Shu-juan1,ZHANG Guang-bao1,RUI Hong-xin1,WU Qian1,HE Yan-lu1,SONG Jun1,CHEN Rong-hua2,GUO Xi-rong1,2,TONG Mei-ling1,2.   

  1. 1 State Key Laboratory of Reproductive Medicine,Department of Pediatrics,Nanjing Maternal and Child Health Care Hospital of Nanjing Medical University,Nanjing,Jiangsu 210004,China;
    2 Institute of Pediatrics of Nanjing Medical University,Nanjing,Jiangsu 210029,China
  • Received:2014-04-24 Online:2014-12-10 Published:2014-12-10
  • Contact: CHI Xia,E-mail:chixia2001@njmu.edu.cn

辅助生殖技术子代4岁龄运动发育结局分析

洪琴1,池霞1,2,杨蕾1,张敏1,刘晓1,张蕾1,乌兰1,解雅春1,窦淑娟1,张光宝1,
芮洪新1,吴茜1,何彦璐1,宋骏1,陈荣华2,郭锡熔1,2,童梅玲1,2   

  1. 1 生殖医学国家重点实验室,南京医科大学附属南京妇幼保健院,江苏 南京 210004;
    2 南京医科大学儿科医学研究所,江苏 南京 210029
  • 通讯作者: 池霞,E-mailchixia2001@njmu.edu.cn
  • 作者简介:洪琴(1982-),女,江苏人,主治医师,博士研究生在读,主要研究方向为发育行为儿科学,儿童神经心理。
  • 基金资助:
    国家自然科学基金项目(81250008);江苏省医学重点人才项目(RC2011022);南京市医学科技发展项目(201108007)

Abstract: Objective To assess the motor developmental outcome at 4 years old children conceived by intracytoplasmic sperm injection (ICSI) and to compare with children conceived naturally. Methods Children enrolled were conceived by ICSI from Jan.2009,through to the end of Dec.2009 in the State key Laboratory of Reproductive Medicine Department of Nanjing Maternity and Child Health Care Hospital.18 ICSI alive single born underwent movement assessments and 36 control subjects as normal control (NC) were matched with respect to age,gender,and birth number.The children were excluded if their gestational weeks less than 32 weeks,birth weight less than 1 500 g,with fetal distress or birth asphyxia history.Children's motor development was assessed with the Movement Assessment Battery of Children (M-ABC) and children sensory integration scale,respectively. Results Physical development:the birth length [ICSI:(48.72±2.52)cm,NC:(50.33±1.24)cm],and birth weight [ICSI:(3.04±0.68)kg,NC:(3.50±0.42)kg] of ICSI group were significantly lower than the control group (P<0.05);at 4 years old,no significant differences were found in the height,weight or head circumference of the two groups(all P>0.05).Motor development:there were no differences in terms of flexibility,hand-eye coordination or total score; However,ICSI group was significantly lower than the control group in balance (ICSI:8.44±1.72,NC:10.92±3.18,P<0.05).Sensory integration capabilities:There were no differences in balance and vestibular double differentiation of the brain,tactile defensiveness,developmental dyspraxia,visual-spatial and shape sensory,the center of gravity or overall evaluation. Conclusion By refining assessment content,expanding the sample size and extending follow-up time,we can provide more powerful evidence for judgment of the long-term developmental outcomes of assisted reproductive offspring.

Key words: assisted reproductive technology, offspring, motor, sensory integration, outcome

摘要: 目的 探讨辅助生殖技术(assisted reproductive technology,ART)对子代远期运动发育结局的影响。方法 选取2009年1-12月在南京市妇幼保健院生殖医学中心进行卵胞浆内单精子注射(intracytoplasmic sperm injection,ICSI)的单胎活产子代18例为研究对象(ICSI),以年龄、性别、胎数为匹配条件,选取在南京市妇幼保健院出生的活产婴儿36例为对照组(NC),排除孕周<32周,体重<1 500 g,有宫内窘迫,出生窒息史者进行研究。利用儿童运动评估系列(Movement Assessment Battery for Children,M-ABC)量表和儿童感觉统合发展检核表(3~6岁)分别比较两组儿童4岁龄的运动及感觉统合能力发育结局。结果 体格发育:ICSI子代出生身长[ICSI:(48.72±2.52)cm,NC:(50.33±1.24)cm]、出生体重[ICSI:(3.04±0.68)kg,NC:(3.50±0.42)kg]均低于对照组,差异有统计学意义(P<0.05);4岁龄,两组的身高、体重及头围均无统计学差异;运动发育:两组在手灵巧度、目标/抓握运动及总分方面无统计学差异(P均>0.05);在平衡能力(ICSI:8.44±1.72,NC:10.92±3.18)方面,ICSI组能力低于对照组,差异有统计学意义(P<0.05)。感觉统合能力:两组在前庭平衡和大脑双分化情况、触觉防御、发育期运用障碍、视觉空间和形状感觉、重心、整体评估差异均无统计学意义(P均>0.05)。结论 通过细化评估内涵、扩大样本量和延长随访时间可以为辅助生殖子代远期发育结局的判断提供更有力的证据。

关键词: 辅助生殖技术, 子代, 运动, 感觉统合, 结局

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