Abstract: Objective To evaluate the effectiveness and safety of the hyperbaric oxygen (HBO) for cerebral palsy (CP) and provide guidance for clinical applications. Methods From Pubmed,Embase,Cochrane library,CNKI,CBM,VIP,Wanfang databases,the randomized controlled studies of HBO for CP were included.Two individuals assessed the quality and extracted data.Statistical analysis was performed by RevMan5.2.7 software. Results A total of 10 studies with 1 111 patients were included in meta-analysis.Meta-analysis showed:HBO did not improve the motor function of children with CP (MD=-5.64,95%CI:-13.98~2.71,P=0.19),activities of daily living.It could ameliorate the muscle tension (RR=3.38,95%CI:2.05~5.58,P<0.05),and had a positive role in developmental quotient,which could improve the efficiency significantly (RR=1.31,95%CI:1.02~1.69,P=0.04) and reduce the inefficiency (RR=0.30,95%CI:0.19~0.50,P<0.001),but the original studies were poor quality with incredibility.In the process of HBO,middle ear barotraumas and earache were common. Conclusions The evidence that HBO could improve the function of the children with CP is insufficient,security also needed further study.More high quality studies in the future are necessary and needed to objective understanding.

Key words: hyperbaric oxygen, cerebral palsy, meta-analysis

摘要： 目的 评价高压氧对脑性瘫痪患儿的疗效及安全性,为临床应用提供指导。方法 检索Pubmed、Embase、Cochrane library、CNKI、CBM、VIP、万方等数据库,筛选高压氧治疗脑瘫患儿的随机对照研究,由两位研究者评价纳入研究的质量、提取数据,采用RevMan 5.2.7软件统计分析。结果 共纳入10项研究,含1 111例患儿。Meta分析结果显示:高压氧治疗并不能改善脑瘫患儿运动功能(MD=-5.64,95%CI:-13.98~2.71,P=0.19)、日常生活功能;能够改善肌张力(RR=3.38,95%CI:2.05~5.58,P<0.05),提高发育商的显效率(RR=1.31,95%CI:1.02~1.69,P=0.04),降低无效率(RR=0.30,95%CI:0.19~0.50,P<0.001),但原始研究质量低,可信度差。同时高压氧治疗过程中存在中耳气压伤、耳痛等不良反应。结论 高压氧治疗对于可提高脑瘫患儿的各项功能状态的证据尚不充分,安全性也有待进一步评估,临床应用需谨慎。需要更多高质量临床研究进一步评价其疗效及安全性。

关键词: 高压氧, 脑性瘫痪, Meta分析