doi:10.11852/zgetbjzz2015-23-10-13

Abstract

摘要： 维生素A (vitamin A,VA)是维持机体正常生理功能不可或缺的营养物质,在人体的视觉、免疫、生长发育及细胞分化等方面发挥广泛而重要的生物学作用。近年来脂溶性维生素尤其是维生素D缺乏作为多发性硬化(multiple sclerosis,MS)独立的病因及危险因素之一在国内得到较多关注,但国内对于维生素A在多发性硬化中的作用关注较少,本文拟针对这一作用进行简要综述,为临床上治疗多发性硬化提供新的方向。

关键词: 多发性硬化, 脂溶性维生素, 维生素A, 视黄酸
中图分类号:R179 文献标识码:A 文章编号:1008-6579(2015)10-1051-02 doi:10.11852/zgetbjzz2015-23-10-13

CLC Number:

R179

杨毅综述, 李廷玉审校. 维生素A辅助治疗多发性硬化的研究进展[J]. 中国儿童保健杂志, 2015, 23(10): 1051-1052.

0
/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://manu41.magtech.com.cn/Jwk_zgetbjzz/EN/10.11852/zgetbjzz2015-23-10-13

https://manu41.magtech.com.cn/Jwk_zgetbjzz/EN/Y2015/V23/I10/1051

References

[1] 黎海芪,毛萌.儿童保健学[M].2版.北京:人民卫生出版社,2010:154-160. [2] Compston A,Coles A.Multiple sclerosis[J].Lancet,2008,372(9648):1502-1517.
[3] Torkildsen ,Lken-Amsrud KI,Wergeland S,et al.Fat-soluble vitamins as disease modulators in multiple sclerosis[J].Acta Neurol Scand Suppl,2013,196:16-23.
[4] Montrone M,Martorelli D,Rosato A,et al.Retinoids as critical modulators of immune functions:new therapeutic perspectives for old compounds[J].Endocr Metab Immune Disord Drug Targets,2009,9(2):113-131.
[5] 洪凯,王雳,顾秋平,等.视黄酸及其受体在机体免疫中的作用[J].免疫学杂志,2012,28(11):990-992.
[6] 孙宇强,王雪,关兴芳,等.维甲酸及其受体与肿瘤关系的研究进展[J].生命科学,2014,26(3):295-301.
[7] Huang JK,Jarjour AA,Nait Oumesmar B,et al.Retinoid X receptor gamma signaling accelerates CNS remyelination[J].Nat Neurosci,2011,14(1):45-53.
[8] Fragoso YD,Stoney PN,McCaffery PJ.The evidence for a beneficial role of vitamin A in multiple sclerosis[J].CNS Drugs,2014,28(4):291-299.
[9] Xu J,Drew PD.9-Cis-retinoic acid suppresses inflammatory responses of microglia and astrocytes[J].J Neuroimmunol,2006,171:135-144.
[10] Besler HT,Comogˇlu S,Okc UZ.Serum levels of antioxidant vitamins and lipid peroxidation in multiple sclerosis[J].Nutr Neurosci,2002,5:215-220.
[11] Royal W,Gartner S,Gajewski CD.Retinol measurements and retinoid receptor gene expression in patients with multiple sclerosis[J].Mult Scler,2002,8:452-458.
[12] Salzer J,Hallmans G,Nystrm M,et al.Vitamin A and systemic inflammation as protective factors in multiple sclerosis[J].Mult Scler,2013,19(8):1046-1051.
[13] 张明宇,陈绪珠.磁共振成像在多发性硬化中的应用:解读2010年西班牙神经科学协会关于磁共振成像对多发性硬化检查推荐规范[J].磁共振成像,2011,2(4):243-251.
[14] 邱世艳,李梅,邓荆月.维生素 A 与多发性硬化[EB/OL].中华临床医师杂志:电子版,2015,9(7):1208-1211.
[15] Lken-Amsrud KI,Myhr KM,Bakke SJ,et al.Retinol levels are associated with magnetic resonance imaging outcomes in multiple sclerosis[J].Mult Scler,2013,19:451-457.
[16] Correale J,Farez MF.Parasite infections in multiple sclerosis modulate immune responses through a retinoic acid-dependent pathway[J].J Immunol,2013,191(7):3827-3837.
[17] Jafarirad S,Siassi F,Harirchian MH,et al.The effect of vitamin A supplementation on biochemical parameters in multiple sclerosis patients[J].Iran Red Crescent Med J,2013,15:194-198.
[18] Bitarafan S,Harirchian MH,Sahraian MA,et al.Impact of vitamin A supplementation on RAR gene expression in multiple sclerosis patients[J].J Mol Neurosci,2013,51(2):478-484.
[19] Madeeh Hashmi A,Awais Aftab M,Mazhar N,et al.The fiery landscape of depression:a review of the inflammatory hypothesis[J].Pak J Med Sci,2013,29(3):877-884.

维生素A辅助治疗多发性硬化的研究进展

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

[1]	XIANG Wei. Early prevention of dyslipidemia in children and adolescents as well as cardiovascular health in adulthood [J]. Chinese Journal of Child Health Care, 2023, 31(7): 697-702.
[2]	WU Ting, LI Fei. Adverse factors in early life and the development and prevention of chronic diseases [J]. Chinese Journal of Child Health Care, 2023, 31(7): 703-706.
[3]	LIU Min, ZHANG Qian, YANG Ting, CHEN Jie, CHEN Li, DAI Ying, JIA Feiyong, WU Lijie, HAO Yan, LI Ling, ZHANG Jie, KE Xiaoyan, YI Mingji, HONG Qi, CHEN Jinjin, FANG Shuanfeng, WANG Yichao, WANG Qi, JIN Chunhua, LI Tingyu. Multi-center survey on serum folic acid in preschool children in China [J]. Chinese Journal of Child Health Care, 2023, 31(7): 713-717.
[4]	HUO Yanyan, LIU Zhongling, MA Ling, WU Dan, WANG Xiulian, QIU Xiaoyan, DOU Jiaying, REN Yuqian, LI Yicheng, HONG Xia, CHEN Jinjin. Status quo and risk factors for different body proportions of children under 2 years old in the real world [J]. Chinese Journal of Child Health Care, 2023, 31(7): 718-723.
[5]	YANG Yuru, WANG Hong, XU Shuhong, CAO Yanmei, MENG Xian, GE Dongmei. Association between bone development and vitamin K in children aged 0 to 14 years [J]. Chinese Journal of Child Health Care, 2023, 31(7): 746-750.
[6]	LI Mingzhu, WANG Jing, XIE Duoshuang. Research progress in the relationship between rapid catch-up growth and childhood obesity in small for gestational age infants [J]. Chinese Journal of Child Health Care, 2023, 31(7): 751-755.
[7]	CAO Hui, YAN Shuangqin, GUAN Hongyan. Influence of parent-child interaction on early childhood development outcome [J]. Chinese Journal of Child Health Care, 2023, 31(7): 770-774.
[8]	SUN Yan, GUO Fei , CHEN Zhiyan. Chain mediating role of family home reading and mother-child intimacy in intergenerational transmission of emotion regulation strategy [J]. Chinese Journal of Child Health Care, 2023, 31(6): 606-611.
[9]	ZHOU Yuanke, LI Yueyue, FANG Bo, SHENG Lulu, WU Wenyi, XI Xuan, LIU Qin. Behavior changes and influencing factors of firstborn children before and after the birth of the second children in a district of Chongqing [J]. Chinese Journal of Child Health Care, 2023, 31(6): 617-622.
[10]	TIAN Tian, SONG Jia, LI Jing, YUAN Hui, SHEN Mengmeng, DING Rong, ZHU Xiaohua, XU Hongze, HU Youfang. Family rearing environment and behavior problems of the second child aged 4 to 6 years in Jiangsu Province [J]. Chinese Journal of Child Health Care, 2023, 31(6): 623-628.
[11]	WANG Ziyang, HU Lei, LIU Jintong. Associations between family relationship and children's sleep [J]. Chinese Journal of Child Health Care, 2023, 31(6): 640-644.
[12]	WANG Dan, HUANG Chuican, FAN Lichun. Research progress in the effects of responsive feeding on sleep of infants and young children [J]. Chinese Journal of Child Health Care, 2023, 31(6): 656-660.
[13]	YU Yabin, WANG Jianhong, XU Qi, WANG Lei, ZHOU Bo, ZHANG Lili, WANG Xi, WANG Lin. Influencing factors of children with developmental stuttering [J]. Chinese Journal of Child Health Care, 2023, 31(6): 674-677.
[14]	LIANG Yijia, WU Honglin, HE Xiumei, HU Xiaohong, HE Xiyu. Types and frequencies of gene variants in idiopathic short stature children [J]. Chinese Journal of Child Health Care, 2023, 31(6): 678-683.
[15]	YING Jiali, CHEN Xiuqin, YANG Chen, HUANG Limei, YU Yan, GAO Xuemei. Moderating role of personality traits in the influence of violent video games on adolescent aggressive behavior [J]. Chinese Journal of Child Health Care, 2023, 31(6): 684-688.