Abstract: Objective To investigate the changes in nutritional status of serum vitamin A and serum iron content before and after the treatment of children with pneumonia,which would provide a new idea for clinical treatment of them. Methods A total of 80 children with pneumonia hospitalized were selected in our department,and were divided into conventional treatment group and vitamin A treatment group.While 30 health check-up children were selected as the control group,respectively detect the levels of retinol binding protein and serum iron content,within 24 hours after admission,10 days after drug treatment.The control group was detected on the day of physical examination,the detection results were compared among 3 groups. Results The retinol binding protein and serum iron content of all pneumonia children within 24 hours after admission was significantly lower than those of the control group,the difference was statistically significant (P<0.05).Compared the conventional treatment group with the vitamin A treatment group,the difference of retinol binding protein and serum iron content were not statistically significant (P>0.05).10 days after drug treatment,the levels of retinol binding protein and serum iron content were increased significantly of all pneumonia children,but there were statistically significant between the conventional treatment group and the control group (P<0.05),and there were no statistically significant between the vitamin A treatment group and the control group(P>0.05). Conclusion There are significant vitamin A deficiency and serum iron content decreased in acute term of pneumonia,with pneumonia is improved,the lever of vitamin A and serum iron content gradually rise.There is a certain relationship between vitamin A deficiency and the occurrence and development of pneumonia,the vitamin A supplement should be noted in the course of treatment of pneumonia.

Key words: pneumonia, vitamin A, retinol binding protein, iron

摘要： 目的 探讨分析肺炎患儿治疗前后血清维生素A营养状况及铁含量的变化,为其临床治疗提供新的思路。方法 选取2013年12月-2014年12月延安大学附属医院儿科收治的80例临床确诊为肺炎住院的患儿为肺炎组,分为常规治疗组和维生素A治疗组;另抽取同期健康体检儿童30例为对照组,对肺炎患儿入院后24 h内和住院治疗10 d后,对照组于体检当天给予采血检测视黄醇结合蛋白和血清铁含量,并对检测结果进行对比。结果 肺炎组所有患儿入院后24 h内视黄醇结合蛋白和血清铁含量明显低于对照组,差异有统计学意义(P<0.05),而肺炎常规治疗组与维生素A治疗组视黄醇结合蛋白和血清铁含量比较差异无统计学意义(P>0.05)。肺炎组住院后10 d视黄醇结合蛋白和血清铁水平明显上升,肺炎常规治疗组与对照组比较差异仍有统计学意义(P<0.05),维生素A治疗组较对照组比较差异无统计学意义(P>0.05)。结论 肺炎急性期存在显著的维生素A缺乏和血清铁含量下降,随着肺炎病情的好转,维生素A缺乏和血清铁含量下降逐渐上升,维生素A缺乏与小儿肺炎的发生及病情发展存在一定的关系,在肺炎的治疗过程中应注意维生素A的补充。

关键词: 肺炎, 维生素A, 视黄醇结合蛋白, 铁