journal1 ›› 2016, Vol. 24 ›› Issue (2): 131-133.DOI: 10.11852/zgetbjzz2016-24-02-06

• Original Articles • Previous Articles     Next Articles

Research of clinical outcome and timing of treatment in neonates with partial hyperthyrotropinemia.

PAN Ling-lin,QIAN Hong-yan,KUANG Xiao-ni,YAN Shu-yuan,ZENG Yu-dong,LIU Yan   

  1. Department of Child Health Care,Maternal and Children's Health Care Hospital of Changsha,Changsha,Hunan 410007,China
  • Received:2015-09-28 Online:2016-02-01 Published:2016-02-01

新生儿部分高促甲状腺素血症的自然转归及治疗时机的临床研究

潘玲琳,钱红艳,匡晓妮,闫淑媛,曾宇东,刘燕   

  1. 长沙市妇幼保健院儿童保健中心,湖南 长沙 410007
  • 作者简介:潘玲琳(1976-),女,新疆人,副主任医师,硕士学位,主要研究方向为儿童心理内分泌及儿童行为发育。
  • 基金资助:
    长沙市科技局立项项目(K10ZD035-13)

Abstract: Objective To investigate the treatment,outcome and influencing factors of neonatal hyperthyrotropinemia and improve the treatment and follow-up level of hyperthyrotropinemia. Methods Neonates were diagnosed hyperthyrotropinemia in 2012~2014.Some were treated with drug whose concentration of thyrotropin were greater than 15 mU/L.The others were followed up whose concentration of thyrotropin were 6.27~15 mU/L.The follow-up group were splited into two groups with a tangent of 10. Results Two follow-up groups with hyperthyrotropinemia had no significant differences in intelligence,length and natural outcome.The thyroid function of about 80% neonates with hyperthyrotropinemia returned to normal within 6 months. Conclusions 1)84.9% neonates are back to normal on their own whose concentration of thyrotropin are less than 15 mU/L.2)Treatment for neonates should be considered comprehensively whose concentration of thyrotropin are 10~15 mU/L.

Key words: hyperthyrotropinemia, outcome, treatment time

摘要: 目的 探讨高促甲状腺素(TSH)血症患儿的治疗、转归及其影响因素,为临床治疗、随访提供参考依据。方法 2012-2014年两年在本院诊断为高TSH血症的新生儿,第一次复查甲状腺功能显示TSH≥15 mU/L者进行药物治疗,TSH(6.27~15 mU/L)者不服药为随访组,以10为切值将随访组分成两组进行随访。结果 两组高TSH血症患儿的智能、身长发育差异无统计学意义,两组的自然转归结果差异亦无统计学意义,随访组中约80%高TSH血症患儿甲状腺功能在半岁以内可恢复正常。结论 1)TSH<15 mU/L的高TSH血症患儿其甲状腺功能约84.9%可自行正常恢复。2)对于10 mU/L ≤TSH<15 mU/L高TSH血症患儿选择治疗时应综合考虑。

关键词: 高TSH血症, 转归, 治疗时机

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