journal1 ›› 2018, Vol. 26 ›› Issue (4): 399-401.DOI: 10.11852/zgetbjzz2018-26-04-14

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Functions and regulation of brain renin-angiotensin system in early development

WU Ling-ling, ZHAO Zheng-yan   

  1. Children's Hospital,Affiliated to School of Medicine,Zhejiang University,Hangzhou,Zhejiang 310053,China
  • Received:2017-06-28 Online:2018-04-10 Published:2018-04-10
  • Contact: ZHAO Zheng-yan,E-mail:zhaozy@zju.edu.cn

大脑肾素-血管紧张素系统在发育早期的功能及调控

吴玲玲, 赵正言   

  1. 浙江大学医学院附属儿童医院,浙江 杭州 310053;
  • 通讯作者: 赵正言,E-mail:zhaozy@zju.edu.cn
  • 作者简介:吴玲玲(1982-),女,浙江人,主治医师,博士学位,主要研究方向为儿童发育行为、神经发育。
  • 基金资助:
    浙江省医药卫生科技项目(H2014KYA125)

Abstract: The classic renin-angiotensin system (RAS) plays an important role in the regulation of blood pressure and body fluid.Recently,major advance in the field of the RAS is the discovery of a complete local RAS in the brain.Brain RAS has all active components of RAS and it is involved in the brain functioning.Brain RAS develops from fetal period and it is easily disturbed by various factors.This review summarizes the articles about the functions and regulation of brain RAS in early development,in order to provide references for further research.

Key words: renin, angiotensin, brain

摘要: 经典的肾素-血管紧张素系统(RAS)在血压和体液调节中起到重要作用。近年来研究者发现大脑内存在着独立的RAS,不仅具备该系统的各种活性成分,而且在大脑功能发挥中起到重要协调作用。已知大脑RAS在胎儿期就开始发育,而在发育早期容易受到各种因素的干扰,因此对相关报道进行回顾总结。

关键词: 肾素, 血管紧张素, 大脑

CLC Number: