Role of protein glycosylation in pediatric central nervous system disorders

doi:10.11852/zgetbjzz2021-0768

Chinese Journal of Child Health Care ›› 2022, Vol. 30 ›› Issue (7): 755-758.DOI: 10.11852/zgetbjzz2021-0768

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Role of protein glycosylation in pediatric central nervous system disorders

REN Yu-qian^*, CHEN Jin-jin

^*Department of Pediatric Intensive Care Unit, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200062, China

Received:2021-05-18 Revised:2021-08-23 Online:2022-07-10 Published:2022-07-25
Contact: CHEN Jin-jin, E-mail:jjvoo@163.com

蛋白质糖基化修饰在儿童中枢神经系统疾病中的作用

任玉倩¹, 陈津津²

上海市儿童医院,上海交通大学医学院附属儿童医院 1.重症医学科; 2.儿童保健科,上海 200062

通讯作者: 陈津津,E-mail:jjvoo@163.com
作者简介:任玉倩(1988-),女,山东人,主治医师,硕士学位,主要研究方向为儿童神经系统发育。
基金资助:
国家自然科学基金(81670810);上海市科委政府间国际合作项目(20410712700);上海市科委医学引导类科技支撑项目(18411967700);上海市卫健委老龄化和妇幼健康专项(2020YJZX0207);上海交通大学“交大之星”计划医工交叉研究基金(YG2019ZDB01);上海市儿童健康服务能力建设专项规划高端儿科海外研修团队培养计划(GDEK201710);上海市临床重点专科项(shslczdzk05705);早产儿神经发育迟缓精准评价与预测的多中心研究(SHDC2020CR1047B)。

Abstract

Abstract: Protein glycosylation is an important post-translational modification, which plays an important role in the formation of protein function and structure.It is involved in many biological activities, such as cell adhesion, migration, intercellular communication, receptor activation, signal transduction and so on.In recent years, it has been found that a variety of glycosylation pathways are involved in the process of brain development.Abnormal glycosylation protein expression has a negative impact on brain development and participates in the occurrence and development of nervous system diseases.In this review, the effects of glycosylation modification of proteins on neural function and the central nervous system diseases in children caused by abnormal glycosylation are discussed, which provides a new perspective for finding new diagnostic biomarkers and therapeutic targets in pediatric central nervous system disorders.

Key words: glycosylated protein, brain development, pediatric central nervous system disorders

摘要： 蛋白质糖基化修饰是一种重要的翻译后修饰,对蛋白质的功能和结构形成具有重要作用,参与调控生物体的多项生命活动,如细胞粘附、转移、细胞间通讯、受体激活、信号转导等。近年来发现多种糖基化途径参与大脑发育的过程,异常的糖基化蛋白表达对大脑发育产生负面影响,并参与神经系统疾病的发生、发展。本文就蛋白质的糖基化修饰对神经功能的影响及糖基化异常导致的儿童中枢神经系统疾病进行论述,为儿童中枢神经系统疾病寻找新的糖基化蛋白诊断标志物和治疗靶点提供视角。

关键词: 糖基化蛋白, 大脑发育, 儿童中枢神经系统疾病

CLC Number:

R748

REN Yu-qian, CHEN Jin-jin. Role of protein glycosylation in pediatric central nervous system disorders[J]. Chinese Journal of Child Health Care, 2022, 30(7): 755-758.

任玉倩, 陈津津. 蛋白质糖基化修饰在儿童中枢神经系统疾病中的作用[J]. 中国儿童保健杂志, 2022, 30(7): 755-758.

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Role of protein glycosylation in pediatric central nervous system disorders

蛋白质糖基化修饰在儿童中枢神经系统疾病中的作用

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