Abstract: Objective To analyze the correlation between endothelial nitric oxide synthase (eNOS) polymorphism (AGT M235T, ACE I/D, eNOS G894T, eNOS T-786C) and encephalopathy of prematurity, in order to provide reference for assessing the patients′ condition comprehensively. Methods Preterm infants with gestational age under 34 weeks in neonatal intensive care unit (NICU) of Xinxiang Central Hospital were enrolled in this study from June 2014 to September 2017. Head ultrasound and magnetic resonance imaging of the patients were conducted, and gene polymorphisms were tested. Clinical data of the participants were retrospectively collected. The correlation among AGT M235T, ACE I/D, eNOS G894T, eNOS T-786C and encephalopathy of prematurity was analyzed. Result It was found that eNOS T-786C TC+CC polymorphism was an independent risk factors for encephalopathy of prematurity (OR＝3.206,95%CI:1.850~7.652). Conclusions There is genetic susceptibility in encephalopathy of prematurity. And gene polymorphism test is helpful to assess the prognosis of preterm infants.

Key words: polymorphism, encephalopathy of prematurity, endothelial nitric oxide synthase, magnetic resonance imaging

摘要： 目的 研究AGT M235T、ACE I/D、eNOS G894T和eNOS T-786C单核苷酸多态性和早产儿脑病发生的关系,为全面评估患儿病情提供参考。方法 选取2014年6月-2017年9月于新乡市中心医院新生儿重症监护室就诊的胎龄<34周的早产儿为研究对象,进行头颅超声和核磁共振影像学检查和基因多态性测定,回顾性分析其临床资料,研究AGT M235T、ACE I/D、eNOS G894T和eNOS T-786C基因多态性和早产儿脑病发生的关系。结果 eNOS T-786C的C等位基因的表达是中重度早产儿脑病的独立危险因素(OR＝3.206,95%CI:1.850~7.652)。结论 早产儿脑病存在基因易感性,检测eNOS基因多态性有助于评估早产儿预后。

关键词: 基因多态性, 早产儿脑病, 内皮型一氧化氮合成酶, 核磁共振成像