journal1 ›› 2019, Vol. 27 ›› Issue (3): 292-295.DOI: 10.11852/zgetbjzz2018-0357

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Study on the correlation of vitamin D levels in infants and their mothers

LIU Ying1,SONG Xiao-hong1,PAN Jian-ping2,SHI Jiao1,LI Min1,LUO Dan1,XIAO Lin1   

  1. 1 Department of Child Health Care,Northwest Women & Children's Hospital,Xi'an,Shaanxi 710061,China;
    2 School of Medical Sciences,Xi'an Jiaotong University,Xi'an,Shaanxi 710061,China
  • Received:2018-03-26 Revised:2018-10-11 Online:2019-03-20 Published:2019-03-20
  • Contact: SONG Xiao-hong,



  1. 1 西北妇女儿童医院儿童保健科,陕西 西安 710061;
    2 西安交通大学医学部,陕西 西安 710061
  • 通讯作者: 宋晓红,
  • 作者简介:刘影(1984-),女,吉林人,硕士学位,主要研究方向为高危儿系统化管理及儿童营养性疾病防治。

Abstract: Objective Toanalyze the correlation of serum vitamin D level between exclusively breast-fed infants aged 28~42 days with clinical manifestation of rickets and their mothers,in order to provide theoretical foundation for prevention of infant nutritional rickets. Methods A total of 119 exclusively breast-fed infants in Northwest Women and Children Hospital,diagnosed with nutritional rickets at age of 28~42 days,were enrolled in this study from April 2016 to October 2017. Serum 25-hydroxylvitamin D [25-(OH)D] level of both infants and their mothers were tested and the correlation was analyzed. Results Among the 119 mothers,15(12.61%) mothers had serum 25-(OH)D level higher than 30 ng/ml,104(87.39%) mothers were no more than 30 ng/ml. Totally 19 mothers took vitamin D supplementation ≥400 U per day during pregnancy,and the median serum level of 25-(OH)D was 28.8 ng/ml. And 100 mothers took vitamin D supplementation less than 400 U per day during pregnancy,and the median serum level of 25-(OH)D was 16.1 ng/ml. The difference on the median serum level of 25-(OH)D between the two groups was significant(P<0.05). Also,there was significant difference on the median serum level of 25-(OH)D between infants with and without vitamin D supplementation(20.0 ng/ml vs.9.5 ng/ml,P<0.05). The serum 25-(OH)D level of infants was positively correlated with theirs mothers' level. No correlation was found between serum 25-(OH)D level(20ng/ml as cutting edge) and the possibility of rickets symptoms and signs. Conclusions The overall vitamin D level of both infants and their mothers is insufficient,and the serum 25-(OH)D level between the infants and their mothers are significantly related. It is suggested to take vitamin D supplementation during pregnancy and to give infants vitamin D supplementation immediately after birth,so as to prevent nutritional rickets in infants.

Key words: 25-(OH)D, rickets, mother, infants

摘要: 目的 分析出生28~42 d出现佝偻病临床表现的纯母乳喂养儿的血清维生素D水平及与其母亲血维生素D水平的相关性,为预防婴儿早期营养性佝偻病的发生提供理论依据。方法 对2016年4月-2017年10月来西北妇女儿童医院儿童保健科正常体检的年龄为28~42 d、并且表现有佝偻病早期症状和(或)体征的119例纯母乳喂养儿及其母亲静脉血25-羟维生素D[25-(OH)D]进行相关性分析。结果 119例母亲血25-(OH)D>30 ng/ml者15例(12.61%),≤30 ng/ml者104例(87.39%);孕期平均每日补充维生素D≥400 U的母亲19例,血25-(OH)D中位数为28.8 ng/ml,每日补充维生素D<400 U母亲100例,血25-(OH)D中位数为16.1 ng/ml,两组血25-(OH)D差异有统计学意义(P<0.05);在119例婴儿中补充和未补充维生素D组的婴儿血25-(OH)D中位数分别为20.0 ng/ml和9.5 ng/ml,两者差异有统计学意义(P<0.05);婴儿血25-(OH)D与其母亲血清25-(OH)D水平呈正相关(r=0.349,P<0.01)。婴儿血25-(OH)D水平(>20 ng/ml和≤20 ng/ml)与其出现佝偻病的症状、体征之间无统计学意义。结论 婴儿及其母亲维生素D整体处于不足水平,两者之间维生素D水平存在相关性。婴儿血25-(OH)D>20 ng/ml并没有降低其发生营养性佝偻病的风险。建议母亲孕期应积极补充维生素D,同时提倡从新生儿一出生即开始补充维生素D,预防婴儿早期营养性佝偻病的发生。

关键词: 25羟维生素D, 佝偻病, 母亲, 婴儿

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