journal1 ›› 2019, Vol. 27 ›› Issue (7): 706-709.DOI: 10.11852/zgetbjzz2018-1169

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Clinical significance of complement C5a and related inflammatory factors in obese children hypertension

YIN Chun-yan, WANG Li, XIAO Yan-feng   

  1. Department of Pediatrics,the Second Affiliated Hospital of Xi′an Jiaotong University,Xi′an,Shaanxi 710004,China
  • Received:2018-10-27 Online:2019-07-10 Published:2019-07-10
  • Contact: XIAO Yan-feng,


尹春燕, 王莉, 肖延风   

  1. 西安交通大学第二附属医院儿科,陕西 西安 710004
  • 通讯作者: 肖延风,
  • 作者简介:尹春燕(1984-),助理研究员,博士学位,主要研究方向为儿童单纯性肥胖及代谢综合征。
  • 基金资助:

Abstract: Objective To analyze the effect of complement C5a and related inflammatory factors on blood pressure and its role in hypertension in obese children,in order to provide scientific reference for clinical intervention. Methods A cross-sectional study was conducted from July 2016 to August 2017 among 71 obese children,recruited from the Second Affiliated Hospital of Xi′an Jiaotong University.Children′s height,weight,waist circumference,body mass index (BMI) and blood pressure were measured.According to the blood pressure measurement results,systolic blood pressure (SBP) and/or diastolic blood pressure(DBP)≥same age P95 as hypertension were further divided into hypertension group and non-hypertension group.Serum insulin,IL-6,C5a,hsCRP and TNF-α were detected by enzyme linked immunosorbent assay(ELISA).The insulin resistance index (HOMA-IR) was calculated and the test results were analyzed. Results The levels of HOMA-IR,triglyceride (TG),total cholesterol (TC),TNF-α,IL-6 and complement C5a in hypertensive children were significantly higher than those in non-hypertensive children (P<0.05).Pearson correlation analysis showed that both SDS-DBP and SDS-SBP were related to the levels of TNF-α,hsCRP,IL-6 and C5a(P<0.05).Multiple linear regression showed that SDS-BMI,waist circumference,IL-6,C5a and hsCRP were significantly correlated with SDS-SBP (P<0.05).Moreover,IL-6,C5a and hsCRP were significantly correlated with SDS-DBP. Conclusion IL-6,hsCRP and C5a play an important role in the development of hypertension in obese children,and may be the risk factors for hypertension

Key words: obese children, hypertension, inflammatory factors, complement C5a

摘要: 目的 分析肥胖患儿体内补体C5a及相关炎性因子对血压的影响及其在高血压中的作用,为临床干预提供科学依据。方法 以2016年7月-2017年8月就诊于西安交通大学第二附属医院小儿内分泌门诊的71例肥胖儿童为研究对象,测量儿童身高、体重、腰围、体重指数(BMI)及血压,根据血压测量结果,收缩压(SBP)和(或)舒张压(DBP)≥同年龄同性别P95为高血压,进一步分为高血压组31例和非高血压组40例。用酶联免疫法检测血中胰岛素、白介素-6(IL-6)、C5a、超敏C反应蛋白(hsCRP)和肿瘤坏死因子-α(TNF-α),并计算胰岛素抵抗指数(HOMA-IR),并对检测结果进行分析。结果 高血压组儿童与非高血压组比较,HOMA-IR、甘油三酯(TG)、总胆固醇(TC)显著升高(P<0.05);此外,肥胖组高血压患儿血中TNF-α,IL-6以及补体C5a显著升高,与非高血压组比较差异均有统计学意义(P<0.05);SDS-DBP及SDS-SBP均与炎性因子TNF-α、hs-CRP、IL-6及补体C5a之间呈显著正相关(P<0.05);多元线性回归显示SDS-BMI、腰围、IL-6、C5a及hsCRP与SDS-SBP显著相关(P<0.05);IL-6、C5a及hsCRP均与SDS-DBP显著相关(P<0.05)。结论 炎性因子IL-6与hsCRP以及补体C5a与肥胖儿童高血压的发生密切相关,可能是引起血压升高的危险因素。

关键词: 肥胖儿童, 高血压, 炎性因子, 补体C5a

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