Abstract: Objective To investigate the effectiveness of life style intervention on preschool children with hyperuricemia(HUA). Methods A cross-sectional survey was carried out in six central urban districts of Tianjin from March to June 2015. And 242 children aged from 3 to 6 years with the elevated blood uric acid levels were randomly divided into the intensive intervention group(n=122) and routine health care group(n=120). Children with the elevated blood uric acid levels in the intensive intervention group were intensively intervened on the diet,exercise guide,health education. Children in both groups were reexamined after at least 3 months,and finally 204 children had reexamination. Results The levels of blood uric acid in the intensive intervention group and in routine health care group were (357.7±44.3)μmol/L and (363.3±44.5)μmol/L at baseline time. The levels of blood uric acid in the intensive intervention group and in routine health care group were (287.6±42.1)μmol/L and (336.2±65.2)μmol/L at reexamination time. The reduction of levels of blood uric acid in the intensive intervention group was more than that in routine health care group and the difference was of statistical significance(t=-4.841,P<0.001). At the time of reexamination,the rates of recovery to the normal level in the intensive intervention group and routine health care group were 72.7% and 44.7%,respectively(χ²=16.586,P<0.001). Conclusion The individualized intervention of life styles and health education may reduce the prevalence of hyperuricemia in preschool children

Key words: elevated blood uric acid level, life style intervention, preschool children

摘要： 目的 对学龄前儿童进行饮食运动干预,分析生活方式指导对儿童血尿酸升高改善的有效性。方法 于2015年3-6月,在天津市城区幼儿园中采用整群抽样方法,随机抽取26所幼儿园4 073名3~6岁儿童进行健康体检,对242名血尿酸升高的儿童(血尿酸≥320 μmol/L)召回随机分为强化干预组(122名)和常规宣教组(120名),对强化干预组给予强化饮食运动的指导干预。干预后至少3个月后复查,共204名儿童完成复查。结果 血尿酸值在强化干预组干预前后分别为(357.7±44.3)μmol/L和(287.6±42.1)μmol/L,常规宣教组干预前后分别为(363.3±44.5)μmol/L和(336.2±65.2)μmol/L,两组下降值强化干预组为(70.1±62.3)μmol/L,常规宣教组为(27.1±64.4)μmol/L,两组间差异有统计学意义(t=-4.841,P<0.001)。强化干预组和常规宣教组分别有72.7%和44.7%的儿童恢复到正常水平(血尿酸<320 μmol/L),差异有统计学意义(χ²=16.586,P<0.001)。结论 经过合理饮食结构和个体化运动锻炼方案为主的生活方式的干预,可以明显降低血尿酸升高儿童的血尿酸值,使其恢复到正常水平。

关键词: 血尿酸升高, 生活方式干预, 学龄前儿童