Research progress on the association between vitamin A and neonatal respiratory diseases

doi:10.11852/zgetbjzz2020-1454

Abstract

Abstract: Vitamin A is a fat-soluble vitamin that participates in a wide range of physiological processes, such as embryonic development, visual development, cell differentiation and proliferation.Retinoic acid (RA) is the main active form of vitamin A, which regulates the development of multiple organs.Sufficient vitamin A is needed during early lung development.Chronic vitamin A deficiency is related to the histopathological changes of the lungs, which can disrupt normal lung physiology, leading to severe respiratory diseases.This review mainly summarizes the relationship between vitamin A and neonatal respiratory diseases, thus to provide guidance for clinical treatment.

Key words: Vitamin A, lung development, congenital diaphragmatic hernia, bronchopulmonary dysplasia, newborn respiratory distress syndrome

摘要： 维生素A是一种脂溶性维生素,它参与广泛的生理过程,如胚胎发育,视觉发育以及细胞分化和增殖。视黄酸(RA)是维生素A主要的活性形式,它调节着多个器官的发育过程。在早期肺发育形成过程中需要足够的维生素A。慢性维生素A缺乏与肺的组织病理学变化有关,这种变化会破坏正常的肺生理,从而导致严重呼吸系统疾病。本文主要对维生素A与新生儿呼吸系统疾病关系做一总结,为临床治疗提供一定的指导。

关键词: 维生素A, 肺发育, 先天性膈疝, 支气管肺发育不良, 新生儿呼吸窘迫综合征

CLC Number:

R725.6

LI Qian-qian, JIANG Hong. Research progress on the association between vitamin A and neonatal respiratory diseases[J]. Chinese Journal of Child Health Care, 2021, 29(5): 523-526.

李倩倩, 姜泓. 维生素A与新生儿呼吸系统疾病关系的研究进展[J]. 中国儿童保健杂志, 2021, 29(5): 523-526.

References

[1] StocksJ, Hislop A, Sonnappa S.Early lung development:lifelong effect on respiratory health and disease[J].Lancet Respir Med, 2013, 1(9):728-742.
[2] World Health Organization.Micronutrients Defificiencies [EB/OL].[2018-04-30].http://www.who.int/nutrition/topics/vad/en/
[3] Schittny, Johannes C .Development of the lung[J].Cell Tissue Res, 2017, 367(3):427-444.
[4] Desai TJ,Malpel S, Flentke GR, et al.Retinoic acid selectively regulates Fgf10 expression and maintains cell identity in the prospective lung field of the developing foregut[J].Dev Biol, 2004, 273(2):402-415.
[5] Fernandes-Silva H, Patrícia Vaz-Cunha, Barbosa VB, et al.Retinoic acid regulates avian lung branching through a molecular network[J].Cell Mol Life Sci, 2017, 74(24):4599-4619.
[6] Schuger L, Varani J, Mitra R, et al.Retinoic acid stimulates mouse lung development by a mechanism involving epithelial-mesenchymal interaction and regulation of epidermal growth factor receptors[J].Dev Biol, 1993, 159(2):462-473.
[7] Montedonico S, Nakazawa N, Puri P .Retinoic acid rescues lung hypoplasia in nitrofen-induced hypoplastic foetal rat lung explants[J].Pediatr Surg Int, 2006, 22(1):2-8.
[8] Pereira TerraP, Moura R, Nogueira-Silva C, et al.Neuroendocrine factors regulate retinoic acid receptors in normal and hypoplastic lung development[J].J Physiol, 2015, 593(15):3301-3311.
[9] Fernandes-Silva H, Patrícia Vaz-Cunha, Barbosa VB, et al.Retinoic acid regulates avian lung branching through a molecular network[J].Cell Mol Life Sci, 2017, 74(24):4599-4619.
[10] Morrisey EE,Hogan BL.Preparing for the first breath:genetic and cellular mechanisms in lung development[J].Dev Cell,2010,18(1):8-23.
[11] Baybutt RC,Hu L, Molteni A.Vitamin A deficiency injures lung and liver parenchyma and impairs function of rat type II pneumocytes[J].J Nutr, 2000, 130(5):1159-1165.
[12] Albertine KH, Jones GP, Starcher BC, et al.Chronic Lung injury in preterm lambs disordered respiratory tract development[J].Am J Respir Crit Care Med, 1999, 159(3):945-958.
[13] 中国城市多中心早产儿呼吸窘迫综合征调查协作组.住院分娩早产儿呼吸窘迫综合征:中国13家医院的回顾性调查[J].中华围产医学杂志,2016,19(10):743-754.
[14] 超未成熟儿与超低出生体重儿研究协作组.广东省超未成熟儿与超低出生体重儿临床救治分析[J].中华儿科杂志, 2019, 57(12):934-942.
[15] Beurskens LW, Schrijver LH, Tibboel D, et al.Dietary vitamin A intake below the recommended daily intake during pregnancy and the risk of congenital diaphragmatic hernia in the offspring[J].Birth Defects Res, 2013, 97(1):60-66.
[16] Loo CKC,Pearen MA, Pereira TN, et al.Lung and liver growth and retinoic acid status in human fetuses with congenital diaphragmatic hernia[J].Early Hum Dev, 2018, 116:17-23.
[17] Kardon G, Ackerman KG, Mcculley DJ, et al.Congenital diaphragmatic hernias:from genes to mechanisms to therapies[J].Dis Model Mech, 2017, 10(8):955-970.
[18] Schmidt AF, Gonçalves FL, Regis AC, et al.Prenatal retinoic acid improves lung vascularization and VEGF expression in CDH rat[J].Am J Obstet Gynecol, 2012, 207(1):76.e25-76.e32.
[19] Michikawa T,Yamazaki S,Sekiyama M, et al.Maternal dietary intake of vitamin A during pregnancy was inversely associated with congenital diaphragmatic hernia:the Japan Environment and Children's Study[J].Br J Nutr,2019,122(11):1295-1302.
[20] McEvoy CT,Jain L, Schmidt B,et al.Bronchopulmonary dysplasia:NHLBI workshop on the primary prevention of chronic lung diseases.[J].Ann Am Thorac Soc,2014,11(3):146-153.
[21] Manuck TA, Levy PT, Gyamfi-Bannerman C,et al.Prenatal and perinatal determinants of lung health and disease in early life:a national heart, lung, and blood institute workshop report[J].JAMA Pediatrics,2016,170(5):e154577.
[22] Jensen EA, Dysart K, Gantz MG, et al.The diagnosis of bronchopulmonary dysplasia in very preterm infants:an evidence-based approach[J].Am J Respir Crit Care Med, 2019,200(6):751-759.
[23] Araki S, Kato S,Namba F, et al.Vitamin A to prevent bronchopulmonary dysplasia in extremely low birth weight infants:a systematic review and meta-analysis[J].PLoS One, 2018, 13(11):e0207730.
[24] Darlow BA, Graham PJ, Rojas-Reyes MX.Vitamin A supplementation to prevent mortality and short- and long-term morbidity in very low birth weight infants[J].Cochrane Database Syst Rev, 2016(8):CD000501.
[25] Ambalavanan N, Kennedy K, Tyson J, et al.Survey of vitamin A supplementation for extremely-low-birth-weight infants:is clinical practice consistent with the evidence?[J].J Pediatr, 2004, 145(3):304-307.
[26] Giridhar S, Kumar J, Attri SV,et al.Intramuscular followed by oral vitamin A supplementation in neonates with birth weight from 750 to 1250 g:a randomized controlled trial[J].Indian J Clin Biochem,2020,35(2):197-204.
[27] Tolia VN, Murthy K, McKinley PS,et al.The effect of the national shortage of vitamin A on death or chronic lung disease in extremely low-birth-weight infants[J].JAMA Pediatrics,2014, 168 (11):1039-1044.
[28] Carnielli VP, Giorgetti C, Simonato M,et al.Neonatal respiratory diseases in the newborn infant:novel insights from stable isotope tracer studies[J].Neonatology,2016,109(4):325-333.
[29] De LucaD, Van Kaam AH, Tingay DG, et al.The Montreux definition of neonatal ARDS:biological and clinical background behind the description of a new entity[J].Lancet Respir Med, 2017,5(8):657-666.
[30] The American College of Committee on Practice Bulletins-Obstetrics, Obstetricians and Gynecologists.Practice bulletin no.130:prediction and prevention of pretermbirth[J].Obstet Gynecol, 2012, 120(4):964-973.
[31] Gao RW, Kong XY, Zhu XX, et al.Retinoic acid promotes primary fetal alveolar epithelial type II cell proliferation and differentiation to alveolar epithelial type I cells[J].In Vitro Cell Dev Biol Anim, 2015, 51(5):479-487.
[32] Singh AJ,Bronshtein V, Khashu M, et al.Vitamin A is systemically bioavailable after intratracheal administration with surfactant in an animal model of newborn respiratory distress[J].Pediatr Res, 2010, 67(6):619-623.
[33] 孟君, 吴洪涛.新生儿呼吸窘迫综合征维生素A、矿物质水平的研究[J].中国儿童保健杂志, 2015, 161(11):1221-1223.
[34] 朱琼, 陈小利, 叶华.维生素A联合牛肺表面活性物质治疗新生儿呼吸窘迫综合征的临床研究[J].现代药物与临床, 2016,31(8):1268-1272.
[35] 程晨, 包蕾.早产儿血清维生素A水平与新生儿呼吸窘迫综合征的相关性分析[J].临床儿科杂志, 2015,33(8):53-56.
[36] Larange A, Cheroutre H .Retinoic acid and retinoic acid receptors as pleiotropic modulators of the immune system[J].Annu Rev Immunol, 2016, 34(1):369-394.
[37] 程雨嘉, 李园, 唐瑾.维生素A缺乏与新生儿感染性肺炎发病相关性研究[J].中国儿童保健杂志, 2019,27(9):1027-1030.
[38] 戴宇卿, 丁丽, 陈越平,等.维生素A与新生儿肺炎,败血症及呼吸窘迫综合征的临床相关研究[J].当代医学, 2018,24(7):25-27.