Chinese Journal of Child Health Care ›› 2021, Vol. 29 ›› Issue (5): 523-526.DOI: 10.11852/zgetbjzz2020-1454

• Review • Previous Articles     Next Articles

Research progress on the association between vitamin A and neonatal respiratory diseases

LI Qian-qian, JIANG Hong   

  1. Department of Neonatology,the Affiliated Hospital of Yan'an University, Yan'an, Shaanxi 716000,China
  • Received:2020-07-29 Revised:2020-10-20 Published:2021-05-26
  • Contact: JIANG Hong,


李倩倩, 姜泓   

  1. 延安大学附属医院新生儿科,陕西 延安 716000
  • 通讯作者: 姜泓,
  • 作者简介:李倩倩(1991-),女,陕西人,硕士在读,主要研究方向为早产儿新生儿危重病。

Abstract: Vitamin A is a fat-soluble vitamin that participates in a wide range of physiological processes, such as embryonic development, visual development, cell differentiation and proliferation.Retinoic acid (RA) is the main active form of vitamin A, which regulates the development of multiple organs.Sufficient vitamin A is needed during early lung development.Chronic vitamin A deficiency is related to the histopathological changes of the lungs, which can disrupt normal lung physiology, leading to severe respiratory diseases.This review mainly summarizes the relationship between vitamin A and neonatal respiratory diseases, thus to provide guidance for clinical treatment.

Key words: Vitamin A, lung development, congenital diaphragmatic hernia, bronchopulmonary dysplasia, newborn respiratory distress syndrome

摘要: 维生素A是一种脂溶性维生素,它参与广泛的生理过程,如胚胎发育,视觉发育以及细胞分化和增殖。视黄酸(RA)是维生素A主要的活性形式,它调节着多个器官的发育过程。在早期肺发育形成过程中需要足够的维生素A。慢性维生素A缺乏与肺的组织病理学变化有关,这种变化会破坏正常的肺生理,从而导致严重呼吸系统疾病。本文主要对维生素A与新生儿呼吸系统疾病关系做一总结,为临床治疗提供一定的指导。

关键词: 维生素A, 肺发育, 先天性膈疝, 支气管肺发育不良, 新生儿呼吸窘迫综合征

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