Abstract: Neonatal sepsis can cause infection in all systems of the body, which is the main cause of neonatal infectious diseases and death. In recent years, different views have been put forward around the risk factors of neonatal sepsis. In addition to preterm birth and low birth weight, vitamin D deficiency is also considered as one of the risk factors for early and late onset sepsis. Premature rupture of membranes and chorionic amnitis, previously considered as risk factors for early sepsis, have also been disputed at present. This article reviews the progress of the above factors and the irrational use of antibiotics, invasive procedures and parenteral nutrition, which lead to late-onset sepsis, as well as other influencing factors, with the aim of providing measures for the prevention of neonatal sepsis.

Key words: early-onset sepsis, late-onset sepsis, newborn

摘要： 新生儿败血症可引起全身各系统的感染,是新生儿感染性疾病发病和死亡的主要原因。近年来围绕新生儿败血症危险因素的研究提出了不同的观点,除了早产与低出生体重,维生素D缺乏也被认为是早发与晚发败血症的高危因素之一。胎膜早破、绒毛膜羊膜炎既往认为是早发败血症的危险因素,目前也提出异议,本文综述了以上因素及不合理应用抗菌药物、有创操作与肠外营养这类导致晚发败血症以及其他影响因素的研究进展,旨在为新生儿败血症的预防提供措施。

关键词: 早发败血症, 晚发败血症, 新生儿