journal1 ›› 2021, Vol. 29 ›› Issue (3): 292-295.DOI: 10.11852/zgetbjzz2020-0360

• Review • Previous Articles     Next Articles

Research progress on hypothermia in the treatment of neonatal hypoxic-ischemic encephalopathy

TIAN Zhi-chen*, ZHANG Xuan, YIN Xiao-juan   

  1. *Department of Pediatrics, Chinese PLA Hospital, Beijing 100700,China; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China
  • Received:2020-03-09 Revised:2020-05-06 Online:2021-03-10 Published:2021-03-10
  • Contact: YIN Xiao-juan,


田智琛1,2, 张宣1,2, 尹晓娟1,2,3   

  1. 1.中国人民解放军总医院儿科医学部,北京 100700;
    2.南方医科大学第二临床医学院,广东 广州 510515;
  • 通讯作者: 尹晓娟,
  • 作者简介:田智琛(1996-),男,广东人,硕士研究生,主要研究方向新生儿脑损伤修复。

Abstract: Hypoxic-ischemic encephalopathy (HIE) is the main cause of neonatal death and disability.Mild hypothermia treatment can significantly reduce the mortality and disability rate of HIE.However, there are still some newborns with lifelong disability in movement, sensation and cognition.Therefore, the implementation conditions of mild hypothermia treatment need to be optimized.This article reviews the pathophysiology of HIE, the neuroprotective effect of hypothermia treatment on HIE, and the influence of various parameters of hypothermia treatment on the neuroprotective effect, so as to provide the basis for better clinical application of hypothermia treatment on HIE.

Key words: newborn, hypoxic-ischemic encephalopathy, hypothermia

摘要: 缺氧缺血性脑病(HIE)是新生儿致死和致残的主要原因,亚低温治疗可显著降低该病的死亡率和致残率,但仍难以避免部分新生儿在运动、感觉和认知方面落后于正常新生儿。因此,亚低温治疗实施的条件有待于优化。本文就新生儿HIE病理生理学、亚低温治疗对新生儿HIE的神经保护作用、亚低温治疗的各种参数对神经保护作用的影响做一综述,以期为临床更好地应用亚低温治疗新生儿HIE提供依据。

关键词: 新生儿, 缺氧缺血性脑病, 亚低温

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