Chinese Journal of Child Health Care ›› 2022, Vol. 30 ›› Issue (11): 1198-1202.DOI: 10.11852/zgetbjzz2022-0037

• Review • Previous Articles     Next Articles

Research progress in adverse neurodevelopmental outcomes of moderate or late preterm infants

ZHANG Yi-min, JIN He-yue, TAO Fang-biao, ZHU Yu-min   

  1. Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University; Key Laboratory of Population Health Across Life Cycle(Anhui Medical University), Ministry of Education of the People's Republic of China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei, Anhui 230032, China
  • Received:2022-01-10 Revised:2022-03-15 Online:2022-11-10 Published:2022-11-09
  • Contact: ZHU Yu-min,


张怡敏, 靳和玥, 陶芳标, 朱昱敏   

  1. 安徽医科大学公共卫生学院儿少卫生与妇幼保健学系;出生人口健康教育部重点实验室(安徽医科大学); 人口健康与优生安徽省重点实验室,安徽 合肥 230032
  • 通讯作者: 朱昱敏,
  • 作者简介:张怡敏(2000-),女,安徽人,在读硕士研究生,主要研究方向为早产儿神经发育疾病。
  • 基金资助:

Abstract: In recent years, the survival rate of premature infants has greatly increased with the continuous improvement of medical level. However, due to insufficient gestational age, premature infants have a higher risk of adverse neurodevelopmental outcomes than full-term infants. And neurodevelopmental problems have gradually become a prominent problem faced by the early development of premature infants. Approximately 80% of the total number of preterm infants is moderate or late preterm infants. However, the correlation between extremely preterm birth and neurodevelopmental disorders is currently well studied, while there are few studies on the correlation between moderate or late preterm birth and neurodevelopmental disorders. In this paper, the neurodevelopmental outcomes of moderate or late preterm infants are reviewed in order to provide evidence for early clinical evaluation. It is of great significance for early intervention by predicting the neurodevelopmental outcome of moderate or late preterm infants by using placenta-brain axis biomarkers.

Key words: moderate or late preterm, infants, neurodevelopment

摘要: 近年来,随着医疗水平的不断提高,早产儿存活率得以大幅提升,但由于胎龄不足,早产儿相比足月儿不良神经发育结局发生的风险比例增高,神经发育问题逐渐成为早产儿早期发展面临的突出问题。中晚期早产儿约占早产儿总人数的80%,但目前极早产和超早产与神经发育障碍相关性的研究较多,中晚期早产与神经发育障碍相关性的研究较少。本文对中晚期早产儿神经发育结局进行综述,为临床早期评估中晚期早产儿神经发育状态提供依据。通过胎盘-脑轴生物标志物预测中晚期早产儿神经发育结局,对开展早期干预具有重要意义。

关键词: 中晚期早产, 婴儿, 神经发育

CLC Number: