Association of vitamin D and its receptor gene polymorphisms with childhood diseases

doi:10.11852/zgetbjzz2022-1371<br/><br/>

Abstract

Abstract: Vitamin D is a fat soluble vitamin, which comes from intestinal absorption and skin synthesis in the human body. It not only participates in the regulation of calcium and phosphorus metabolism, but also is related to the metabolic regulation of endocrine, immune, respiratory and other multiple systems. Vitamin D receptor and its gene polymorphism are important components of the biological effect of vitamin D in human body. This article reviews the researches on serum vitamin D level, vitamin D receptor gene polymorphism and children's respiratory, immune and other systems, as well as children's growth, development, metabolism and other related diseases at home and abroad in recent years, in order to provide reference for further researches on vitamin D and its receptor gene polymorphism in children's diseases, as well as and the prevention and treatment of diseases.

Key words: vitamin D, vitamin D receptor gene, polymorphism, childhood diseases

摘要： 人体内的维生素D源于肠道吸收及皮肤合成,属于脂溶性维生素,它不仅参与机体钙磷代谢的调节,还与内分泌、免疫、呼吸等多系统代谢调节相关。而维生素D受体及其基因多态性是维生素D在人体内发挥生物学效应的重要组成部分。本文就近些年来国内外关于血清维生素D水平、维生素D受体基因多态性与儿童呼吸、免疫等系统以及儿童生长发育、代谢等相关疾病的研究进行综述,为维生素D及其受体基因多态性在儿童疾病方面的研究及疾病的预防、治疗起到积极作用。

关键词: 维生素D, 维生素D受体基因, 多态性, 儿童疾病

CLC Number:

CUI Yifan, XIAO Xuwu. Association of vitamin D and its receptor gene polymorphisms with childhood diseases[J]. Chinese Journal of Child Health Care, 2023, 31(10): 1111-1115.

崔一帆, 肖绪武. 维生素D及其受体基因多态性与儿童疾病的相关性[J]. 中国儿童保健杂志, 2023, 31(10): 1111-1115.

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