Abstract: Objective To investigate the correlation of calcium and vitamin D levels with body length development of 2- to 3-year-old children, so as to provide theoretical basis for the intervention of physical development deviation. Methods A retrospective analysis was performed on the clinical data of 204 children aged 2 to 3 years who underwent routine physical examination in the Department of Child Health of Northwest Women and Children's Hospital from September 2019 to June 2021.Standard physical measurements and previous calcium and vitamin D supplementation were collected retrospectively in the form of a questionnaire, and serum 25-(OH) D level and bone mineral density were measured. Spearman correlation and Logistic multifactor regression analysis were used to analyze the correlation of calcium and vitamin D levels with physical development. Results The median daily dose of vitamin D supplementation was 569.5 U, and the median of serum 25-(OH)D was 35.60 ng/dl in 204 children. The deficiency, insufficiency, sufficiency rates of vitamin D were 1.96%, 0.98% and 97.06%, respectively. No children took in excessive vitamin D. The median bone mineral density(BMD) was P64.0. Univariate Spearman rank correlation analysis indicated that the daily average supplementation doses of vitamin D and calcium were both positively correlated with body length(r=0.172, 0.213, P<0.05), while the bone mineral density was negatively correlated with body length(r=-0.138, P<0.05). Multivariate Logistic regression analysis showed that the average daily calcium supplementation dose was positively correlated with body length, with statistical significance(OR=1.003, 95%CI:1.001 - 1.006, P<0.05), while daily vitamin D supplementation dose and bone mineral density were not found to be significantly related to body length. Conclusion Continuous supplementation of calcium can promote the body length development of 2- to 3-year-old children.

Key words: calcium, body length, 25-hydroxyl vitamin D, bone mineral density

摘要： 目的 分析钙与维生素D(VitD)的营养情况与2～3岁幼儿身长发育的相关性,为体格发育偏离干预提供一定理论依据。 方法 回顾性分析在2019年9月—2021年6月西北妇女儿童医院儿童保健科常规体检的204例幼儿(年龄2～3岁)的临床资料。对这些幼儿进行标准体格测量和对其既往钙和维生素D的补充情况以问卷形式进行回顾性调查,同时检测儿童的血清25-(OH)D和骨密度。对体格发育情况与钙和VitD的营养状况采用了Spearman相关及Logistic多因素回归分析等方法进行统计学分析。结果 每日平均补充VitD剂量的中位数为569.5 U,204例幼儿血清25-(OH)D的中位数为35.60 ng/dl。VitD缺乏检出率1.96%、不足检出率0.98%、充足检出率97.06%,无VitD过量;骨密度中位数为P64.0;单因素Spearman秩相关分析显示,每日平均补充VitD的剂量和每日平均补充钙剂量均与身长呈正相关(r=0.172、0.213,P＜0.05);骨密度与身长呈负相关(r=-0.138,P＜0.05);多因素Logistics回归分析显示,每日平均补充钙剂量与身长呈正相关(OR=1.003,95%CI :1.001~1.006,P＜0.05),而每日平均补充VitD剂量及骨密度与身长无显著相关性。结论 持续补充钙剂对2～3岁幼儿的身长发育有良好的促进作用。

关键词: 钙, 身长, 25羟维生素D, 骨密度