Effects of proanthocyanidins on the expression of Aβ, tau and SOD protein with Alzheimer disease in rats

Abstract

Abstract: AIM: To observe the effects of proanthocyanidins on Aβ, tau and SOD with Alzheimer disease in rats.METHODS: AD model was mimicked by intraperitoneal injecting D-gal (180 mg·kg^-1·d^-1) and intragastric administrating AlCl₃ (15 mg·kg^-1·d^-1) for 12 weeks. Then AD rats who were built successfully were randomly divided into 4 groups, model group, proanthocyanidins low-dose group, proanthocyanidins high-dose group, VitE group, but control group was set up by intraperitoneal injecting NS and intragastric administrating NS for 12 weeks, in additional. After that, each group was intragastric administrated with different drugs, control group (NS i.p.), model group(D-gal i.p.+AlCl₃ i.g.), proanthocyanidins low-dose group (PC 20 mg/kg), proanthocyanidins high-dose group (PC 40 mg/kg), VitE group (VitE 10 mg/kg) for 8 weeks. The expression of Aβ, SOD, tau protein were detected with Western blot.RESULTS: As compared with control group, the expressions of Aβ and tau protein were higher and SOD was lower in model group (P<0.01). However, the expression of Aβ and tau protein decreased and SOD increased in proanthocyanidins high-dose group (40 mg/kg), there was statistically significant difference between PC high-dose group and model group (P<0.01, P<0.05).CONCLUSION: Proanthocyanidins has protective effects on Alzheimer disease in rats.

Key words: proanthocyanidins, Alzheimer disease, Aβ, tau, SOD

CLC Number:

R965.2

MA Yu-hong, YAO Hai, WANG Huan, YANG Jie-ren. Effects of proanthocyanidins on the expression of Aβ, tau and SOD protein with Alzheimer disease in rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2014, 19(3): 280-283.

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