Abstract: AIM: To observe the influence of dexmedetomidine on analgesic quality of patient controlled intravenous analgesia with tramadol after laparoscopy assisted radical gastrectomy. METHODS: Sixty patients scheduled to undergo laparoscopy assisted radical gastrectomy were randomly assigned to two groups (observation and control group) with 30 each. All patients were given general anesthesia and PCIA with tramadol 800 mg and tropisetron 5 mg. Dexmedetomidine 200 μg was added to PCIA in observation group. MAP, HR, RR, SpO₂ was determined before anesthesia(T0) and at 2 hours(T1), 4 hours(T2), 8 hours(T3), 12 hours(T4) and 24 hours(T5) after operation.Postoperative pain was assessed by visual analogue score(VAS) at T1-T5. The total dose of tramadol and pressure times of PCIA within 24 hours after operation, cases of using pethidine, bradycardia, hypotension, hypoxemia, excessive sedation, nausea, vomiting were also recorded. RESULTS: Compared with the control group,the MAP, HR, VAS were lower at T1-T4 in observation group(P<0.05). MAP, HR were higher at T1-T4 than those at T0, T5 in control group(P<0.05). Compared with control group, the total dose of tramadol, pressure times of PCIA, cases of using pethidine and incident of nausea were less than those in observation group(P<0.05). CONCLUSION: Dexmedetomidine can improve the quality of PCIA with tramadol, decrease the dose of tramadol and reduce the incident of nausea after laparoscopy assisted radical gastrectomy.

Key words: dexmedetomidine, patient controlled intravenous analgesia, tramadol, laparoscopy assisted radical gastrectomy