Research on the progress of alcoholic liver disease pathogenesis related to CYP2E1

Abstract

Abstract:

Alcoholic liver disease (ALD) is a kind of liver damage caused by long-term drink or heavy drink by a couple of weeks. Cytochrome P450 2E1 (CYP2E1), as a main enzyme metabolizing enzyme of alcohol, plays an important role in the toxic metabolism of alcohol and the occurrence and development of ALD. The expression of CYP2E1 in vivo, the activity of CYP2E1 and free oxygen radicals and toxic metabolites produced during the metabolism of alcohol by CYP2E1 can affect the process and development of ALD in different ways. The regulation mechanisms related to CYP2E1 is involved with multiples of pathogenic molecules, pathogenesis and signaling pathways. The interplay and reciprocal action between signaling pathways could have an influence on self-protection and the occurrence and development of ALD. This review mainly summarizes the research progresses of signaling pathways both in protective and injury mechanisms that regulate the progress of ALD through CYP2E1. Our effort could provide help for the prevention and treatment of ALD in future.

Key words: alcoholic liver disease, CYP2E1, Wnt - beta - catenin, JNK-MAPK/NF-κB, TGF-β-Smads

CLC Number:

R969
R968

CHEN Dan, LIN Xiuxian, CHEN Yao. Research on the progress of alcoholic liver disease pathogenesis related to CYP2E1[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(2): 198-203.

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