Abstract: Objective To understand present situation and change rule and influence factors of ultrasonic bone mineral density of the city children under the age of six, to provide reference data of normal population and the work direction for bone health care of children. Methods From June 2011 to December 2012, bone mineral density testing of healthy children in our hospital detected 7 064, including male 3 681, female 3 383.Using Israel Omnisense 7000P type of quantitative ultrasound bone density detector, in accordance with the standards for bone mineral density testing, the left tibia interrupt point for babies under 3 years old the radial 1/3 as the measurement point for the children aged ≥3, the ultrasonic speed (the speed of sound, SOS) value were measured.At the same time, application of self-made questionnaires, to parents of children collected with accurate records of children including the children's date of birth, family income, educational level of parents, parenting culture degree, family type, pregnant condition, feeding, vitamin D and calcium supplementation, the time for outdoor activities, there is no familial bone disease and other major diseases. Results The normal range of ultrasonic bone mineral density values of children below 6 years old in 1, 12, 24, 36, 48, 60 months old were:(2 877.23±214.44), (3 275.32±215.89), (3 459.66±195.60), (3 577.46±300.45), (3 605.55±288.53), (3 642.49±288.04)m/s, with the age increasing gradually increase.Within 3 years old the bone mineral density increased rapidly, especially infants.After the age of 3, bone mineral density increased slowly, there was a significant difference between different age groups (P<0.01).Among all age groups, the t test showed that differences between boys and girls had no statistical significance (P＞0.05).Multiple conditional Logistic regression analysis showed:mother late gestation supplement vitamin D, given daily oral vitamin D in children aged, active/passive movement, timely add animal food, outdoor activities are protective factors of bone mineral density in children. Conclusions The establishment of ultrasonic bone mineral density normal range values in children under the age of 6.Can provide clinical reference for the future of children's bone health Yidu city.

Key words: ultrasound, bone mineral density, children

摘要： 目的 了解宜都市6岁以下儿童超声骨密度的现状及变化规律、影响因素, 为儿童骨健康保健工作提供正常人群参考数据和工作方向。方法 选择2011年6月-2012年12月在宜都市妇幼保健院儿童保健科进行骨密度检测的健康儿童, 共检测7 064名, 其中男3 681名, 女3 383名。使用以色列SunLight公司的Omnisense 7000P型定量超声骨密度检测仪, 由专人按标准进行骨密度检测。3岁以下儿童选取左侧胫骨中段为测量点, 3岁以上儿童选取桡骨前1/3 处为测量点, 测量其超声速度值。同时应用自制的调查表对受试儿童家长进行问卷调查, 准确记录受试儿童出生日期, 家庭经济收入、父母文化程度、养育人文化程度、家庭类型、母亲孕期情况、喂养情况、补充维生素D和钙情况、户外活动时间、有无家族性骨骼疾病及其他重大疾病。结果 宜都市6岁以下儿童在1、12、24、36、48、60月龄时超声骨密度正常范围值分别为:(2 877.23±214.44)、(3 275.32±215.89)、(3 459.66±195.60)、(3 577.46±300.45)、(3 605.55±288.53)和(3 642.49±288.04)m/s, 随月龄增长而逐渐增加。3岁以内骨密度增长迅速, 尤其是婴儿期, 3岁以后骨密度增加明显变缓, 各年龄组之间差异有高度统计学意义(P＜0.01)。各月龄组男女童之间差异均无统计学意义(P>0.05)。多因素条件Logistic回归分析显示:母亲孕后期补充维生素D、0～2岁儿童每天口服维生素D、参加主/被动运动、及时添加动物性食物、户外活动是增加儿童骨密度的保护因素。结论 建立了宜都市6岁以下儿童超声骨密度正常范围值, 为今后儿童骨健康保健提供临床参考。

关键词: 超声, 骨密度, 儿童