Chinese Journal of Child Health Care ›› 2021, Vol. 29 ›› Issue (5): 506-509.DOI: 10.11852/zgetbjzz2020-0707

• Review • Previous Articles     Next Articles

Application of melatonin in children's sleep research and its measurement methods

JIN Wei-qi*, HAN Dong-mei, WANG Guang-hai, LI Gui-pu, JIANG Fan   

  1. *Department of Development and Behavioral Pediatrics,Shanghai Key Laboratory of Children's Environmental Health,Shanghai Children's Medical Center,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China
  • Received:2020-04-17 Revised:2020-05-11 Published:2021-05-26
  • Contact: JIANG Fan,E-mail:fanjiang@shsmu.edu.cn

褪黑素在儿童睡眠研究中的应用及检测方法

金伟琦1, 韩冬梅2, 王广海1, 李归浦3, 江帆1   

  1. 1.上海交通大学医学院附属上海儿童医学中心发育行为儿科,教育部上海环境与儿童健康重点实验室,上海 200127;
    2.上海交通大学医学院基础医学公共技术平台;
    3.贝因美(杭州)食品研究院有限公司
  • 通讯作者: 江帆,E-mail:fanjiang@shsmu.edu.cn
  • 作者简介:金伟琦(1995-),女,硕士研究生在读,主要研究方向为儿童睡眠。
  • 基金资助:
    国家自然科学基金面上项目(81773443);国家重点研发计划重大慢病防控研究重点专项(2016YFC1305203);上海交通大学 “医工交叉研究基金”重点项目(YG2016ZD04);上海市科委优秀学术带头人计划(17XD1402800);贝因美食品研究院基金项目(RD04614026C)

Abstract: Melatonin is an indoleamine hormone with various physiological functions.In recent years,it has attracted much attention in evaluating circadian rhythm and improving sleep.Melatonin research in children has also gradually increased,but there is currently a lack of sensitive and accurate melanin detection methods.Therefore,this article mainly reviews the changes in melatonin's characteristics in early life,the application of children's sleep research,as well as the collection and detection methods,in order to provide a certain reference value for clinical treatment of sleep problems such as sleep rhythm disorders in children.

Key words: melatonin, circadian rhythm, sleep, children

摘要: 褪黑素是一种具有多种生理作用的吲哚胺类激素,近年来其在评估昼夜节律及改善睡眠方面备受瞩目,儿童褪黑素研究也逐渐增多,但目前缺乏灵敏精确的儿童褪黑素检测方法。因此,本文主要就褪黑素在生命早期的特征变化、儿童睡眠研究中的应用及其采集检测方法进行综述,为临床处理儿童睡眠节律紊乱等睡眠问题提供一定的参考。

关键词: 褪黑素, 昼夜节律, 睡眠, 儿童

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