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中国临床药理学与治疗学 ›› 2018, Vol. 23 ›› Issue (6): 678-681.doi: 10.12092/j.issn.1009-2501.2018.06.013

• 药物治疗学 • 上一篇    下一篇

抚触联合益生菌早期干预对晚期早产儿黄疸的影响

余金晶,张彦萍,潘家华   

  1. 中国科学技术大学附属第一医院(安徽省立医院)儿科,合肥 230001,安徽
  • 收稿日期:2018-03-26 修回日期:2018-04-18 出版日期:2018-06-26 发布日期:2018-06-19
  • 通讯作者: 潘家华,男,硕士,主任医师,硕导,研究方向:新生儿消化性疾病与儿童哮喘。 Tel:13866167758 E-mail:panjiahua1960@163.com
  • 作者简介:余金晶,女,硕士,主治医师,研究方向:新生儿消化性疾病。 Tel:18956078852 E-mail:yjj2172897@163.com
  • 基金资助:

    安徽省公益性研究联动项目(1501ld04016)

Effects of early intervention of massage combined with probiotics on neonatal jaundice of later period preterm infants

YU Jinjing, ZHANG Yanping, PAN Jiahua   

  1. Department of Pediatrics, the First Affiliated Hospital of USTC,D ivision of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, Anhui, China
  • Received:2018-03-26 Revised:2018-04-18 Online:2018-06-26 Published:2018-06-19

摘要:

目的:评价抚触联合益生菌早期干预对晚期早产儿黄疸的影响。方法:选取新生儿室收治的晚期早产儿242例,采用随机数字表法,将患儿分为抚触组和对照组,经过排除和剔除182例患儿后,每组各有30例完成研究。抚触组和对照组均在患儿开奶后,给予双歧杆菌三联活菌,直到生后第4天;抚触组在患儿生后第1天即给予抚触干预,直到生后第4天。对照组不接受抚触干预。记录患儿开奶时间,首次排便时间,生后第1~4天每天的大便次数、经皮胆红素水平,检测生后第4天血清胆红素水平,观察是否有腹胀、腹泻、呕吐、感染等并发症。结果:与对照组相比,抚触组患儿在生后第2~4天每天的排便次数明显多于对照组(P<0.05);与对照组相比,抚触组患儿在生后第3~4天经皮胆红素水平明显低于对照组(P<0.05);与对照组相比,抚触组患儿在生后第4天血清胆红素水平明显低于对照组(P<0.05);两组患儿均无腹胀、腹泻、呕吐、感染等并发症的发生。结论:抚触联合益生菌早期干预可以明显降低晚期早产儿生后第4天的胆红素水平。

关键词: 新生儿黄疸, 抚触, 益生菌, 经皮胆红素

Abstract:

AIM: To investigate the effects of early intervention of massage combined with probiotics on neonatal jaundice of later period preterm infants. METHODS: A total of 242 later period preterm infants in neonatology department were included in this study.The infants were randomly allocated to massage group and control group. After excluding 182 cases, thirty cases in each group completed the research. Both the massage group and the control group were given bifid triple viable from first feeding time to the fourth day after birth. The massage group received massage therapy for four days from the first day postnatal while the control group received routine care. The first feeding time, the first defecation time,the daily stool frequency and the transcutaneous bilirubin level (for four days from the first day postnatal) were recorded, and the serum bilirubin level on the fourth day postnatal was also detected to investigate whether they have complications, such as ventosity, diarrhea, vomiting, infection and other complications. RESULTS: Compared with the control group, the number of defecation times of the infants in the massage group was more than that of the control group on day 2-4 after birth (P<0.05); the transcutaneous bilirubin level in the massage group was significantly lower than the control group on day 3-4 after birth (P<0.05); the serum bilirubin level of the infants in the massage group was significantly lower than that of the control group on the fourth day after birth (P<0.05). There were no complications such as ventosity, diarrhea, vomiting and infection in the two groups. CONCLUSION: Early intervention of massage combined with probiotics can significantly reduce the level of bilirubin on day 4 after birth in later period preterm infants.

Key words: neonatal jaundice, massage, probiotics, transcutaneous bilirubin

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