新的抗肿瘤药7-hy droxy staurosporine(UCN-01)抑制肿瘤浸润和转移

中国临床药理学与治疗学 ›› 2000, Vol. 5 ›› Issue (4): 289-293.

• 论著 • 下一篇

新的抗肿瘤药7-hy droxy staurosporine(UCN-01)抑制肿瘤浸润和转移

孟庆慧, 邵荣光¹, 徐静文², 樊赛军

长岛Jewish 医学中心分子肿瘤实验室, 纽约美国

收稿日期:2000-08-01 修回日期:2000-10-20 出版日期:2000-12-26 发布日期:2020-11-27

Suppression of invasion and migration by 7-hydroxystaurosporine(UCN-01), a new ant i-tumor agent

MENG Qing-Hui, SHAO Rong-Guang¹, XU Jing-Wen², FAN Sai-Jun^*

Laboratory of Molecular Oncology, Department of Radiation Oncology ,Long Island Jewish Medical Center, New York;
¹Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing, China;
²Division of Rheumatology, Department of Medicine ,The Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York, USA

Received:2000-08-01 Revised:2000-10-20 Online:2000-12-26 Published:2020-11-27
Contact: Saijun Fan, MD, Ph.D, Laboratory of Molecular Oncology, Department of Radiation Oncology, Lon g Island Jewish Medical Center(The Long Island Campus for the Albert Einstein College of Medicine)270-05,76th Avenue, New Hyde Park, New York 11040 Tel:718-470-7456 Fax:501-423-3792 e-mail:fan@lij.edu

摘要/Abstract

摘要： 目的和方法 研究7-hydroxystaurosporine(UCN-01)对转移性前列腺肿瘤DU-1 45 细胞浸润和转移的影响。用体外转移和创伤法检查细胞浸润和转移,用Western blotting法检查蛋白质的表达。结果 UCN-01 在非毒性剂量下(100 nmol·L^-1)明显地抑制DU-145细胞浸润和转移。而且,UCN-01这种抗肿瘤浸润和转移功能与它增加细胞-细胞粘连分子E-cadherion的表达有关。结论这些实验首次证实UCN-01 能抑制人前列腺肿瘤细胞的浸润和转移。UCN-01 的临床应用可能更有效地控制前列腺肿瘤转移。

关键词: 7-hydroxystaurosporine(UCN-01), 前列腺, 肿瘤, 浸润, 转移

Abstract: Aim and Methods To investigate the effect of UCN-01(7-hydroxystaurosporine)on cell migration and invasion ability of DU-145, an invasive human pro state cancer cell line.Results It was found that UCN-01 at no n-cytotoxic doses (100 nmol·L^-1)significantly inhibited prostate cancer DU-145 cell invasion and migration behaviors.Moreover, this anti-invasion and migration activity of UCN-01 was associated with an up-regulation of cell adhesion molecule E-cadherin.Conclusion These results indicate for first time that UCN-01 inhibits the invasion and migration of human prostate cancer cells.Thus, clinical application of UCN-01 may contribute to the potential benefit for suppression of prostate cancer invasion and metastasis.

Key words: 7-hydroxystaurosporine(UCN-0 1), prostate, tumor, invasion, migration

中图分类号:

R979.1

孟庆慧, 邵荣光, 徐静文, 樊赛军. 新的抗肿瘤药7-hy droxy staurosporine(UCN-01)抑制肿瘤浸润和转移[J]. 中国临床药理学与治疗学, 2000, 5(4): 289-293.

MENG Qing-Hui, SHAO Rong-Guang, XU Jing-Wen, FAN Sai-Jun. Suppression of invasion and migration by 7-hydroxystaurosporine(UCN-01), a new ant i-tumor agent[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2000, 5(4): 289-293.

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新的抗肿瘤药7-hy droxy staurosporine(UCN-01)抑制肿瘤浸润和转移

Suppression of invasion and migration by 7-hydroxystaurosporine(UCN-01), a new ant i-tumor agent

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