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中国临床药理学与治疗学 ›› 2002, Vol. 7 ›› Issue (3): 221-223.

• 基础研究 • 上一篇    下一篇

大鼠血糖的昼夜节律及格列吡嗪对糖尿病大鼠的时间治疗学

刘晓平, 郭祖峰, 汪长生, 王娟, 崔海鞠, 杨解人, 宋建国   

  1. 皖南医学院药理教研室, 芜湖 241001
  • 收稿日期:2001-09-19 修回日期:2001-10-12 发布日期:2020-12-01
  • 通讯作者: 刘晓平, 男, 硕士。Tel:0553-3832468-6264 E-mail:lin8xiaoping@sina.com
  • 作者简介:宋建国, 男, 教授, 院长, 硕士生导师。

Circadian rhythm of blood sugar in rats and chronotherapeutics of glop-izide in diabetic rats

LIU Xiao-Ping, GUO Zu-Feng, WANG Chang-Sheng, WANG Juan, CUI Hai-Ju, YANG Jie-Ren, SONG Jian-Guo   

  1. Department of Pharmacology, Wannan Medical College, Wuhu, Anhui 241001
  • Received:2001-09-19 Revised:2001-10-12 Published:2020-12-01

摘要: 目的: 研究正常大鼠及糖尿病大鼠血糖变化的昼夜节律;对格列吡嗪治疗糖尿病大鼠的药效进行时间治疗学研究, 以探索合适的用药时间。方法: 测定正常大鼠及糖尿病大鼠 6 ∶00 、12 ∶00 、18 ∶00 、 0 ∶00 的血糖, 分析其昼夜节律性;分别于 9 ∶00或21 ∶00 用格列吡嗪灌胃糖尿病大鼠, 比较不同时间点治疗后各组的平均血糖及血糖波动情况。结果: 正常大鼠血糖变化呈明显昼夜节律性, 糖尿病大鼠血糖变化无明显昼夜节律;9 ∶00 用格列吡嗪治疗糖尿病大鼠时, 其平均血糖及血糖波动值均小于 21 ∶00 用药组。结论: 正常大鼠血糖变化有昼夜节律性;用格列吡嗪治疗糖尿病大鼠, 早晨用药疗效优于晚上用药。

关键词: 时间生物学, 糖尿病, 时间治疗学, 大鼠, 格列吡嗪

Abstract: AIM: To investigate the circadian rhythm of blood sugar level in healthy as well as diabetic rats and tofind the appropriate timefor using glopizide in diabetic rats.METHODS: The blood sugar level of two kinds of rats was detected at 6 ∶00, 12 ∶00, 18 ∶00, 0 ∶00 and circadian rhythm of the data was analyzed.Different groups of diabetic rats were treated with glopizide at 9 ∶ 00 or 21 ∶00 respectively.The variation of blood sugar level andits average were compared between groups after the treatment.RESULTS: Significant circadian rhythm of the blood sugar level was foundin healthy rats, but not in diabetes rats.The variation of blood sugar level andits average were lower when glopizide was given at 9 ∶00 than those at 21 ∶00.CONCLUSION: There is a circa-dian rhythm of blood sugar level in healthy rats and glop-izide shows a better action of decreasing blood sugar in the morning than evening.

Key words: chronobiology, diabetes, chronothera-peutics, rats, glopizide

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