阿片类药物依赖的治疗学进展

中国临床药理学与治疗学 ›› 2003, Vol. 8 ›› Issue (1): 111-114.

阿片类药物依赖的治疗学进展

李琳, 吴航宇综述, 徐江平审校

第一军医大学基础部药理学教研室, 广州 510515

收稿日期:2002-10-23 修回日期:2002-10-29 发布日期:2020-11-25
通讯作者: 徐江平, 男, 教授, 博士, 研究方向:神经药理学。Tel:020-61648236 E-mail:xjp@f immu.com
作者简介:李琳, 女, 助教, 在读硕士, 研究方向:吗啡依赖性防治研究。Tel:020-61648235 E-mail:li75lin@21cn.com

Progress in therapeutics of drug dependence by opioids

LI Lin, WU Hang-Yu, XU Jiang-Ping

Department of Pharmacology, First Military Medical University, Guangzhou 510515

Received:2002-10-23 Revised:2002-10-29 Published:2020-11-25

摘要/Abstract

摘要： 介绍阿片类物质依赖的主要药物治疗学进展, 主要包括三个步骤, 重点介绍阿片受体激动药和非阿片受体激动药的使用, 此外尚有非药物疗法及免疫疗法等。

关键词: 药理学, 综述, 阿片类药物, 药物依赖, 免疫疗法

Abstract: This paper described the progress in therapeutics of drug dependence by opioids, involved in usages of opiate receptor agitations, non-opiate receptor agitations,non-drug treatment, and immunosuppressive therapy.

Key words: pharmacology, review, opioids, drug dependence, immunosuppressive therapy

中图分类号:

R971.2
R453

李琳, 吴航宇, 徐江平. 阿片类药物依赖的治疗学进展[J]. 中国临床药理学与治疗学, 2003, 8(1): 111-114.

LI Lin, WU Hang-Yu, XU Jiang-Ping. Progress in therapeutics of drug dependence by opioids[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2003, 8(1): 111-114.

参考文献

[1] Kreek MJ, LaForge KS, Butelman E.Pharmacotherapy of addictions[J].Nat Rev Drug Discov 2002;1:710-26
[2] Koch M, Banys P.Methadone is a medication, not an addiction [J].Liver Transpl, 2002;8:783-6
[3] Strain EC, Stetzer ML, Lieblon LA, et al.Comparison of buprenorphine and methadone in the treatment of opioid dependence[J].AM J psychiatry, 1994;151:1025
[4] Gold MS.Opiate addiction and the locus coeruleus.The clinical utility of clonidine, naltrexone, methadone, and buprenorphine [J].Psychiatr Clin North Am, 1993;16:61-73
[5] 杨国栋, 周文华, 张富强.选择性毒蕈碱受体拮抗剂减轻吗啡耐受和依赖的实验研究[J].中华医学杂志, 1997;77:130-3
[6] Ramaswamy S, Bapna JS.Antagonism of morphine tolerance and dependence by metoclopramide[J].Life Sci, 1987;40:807-10
[7] Anagnostakis Y, Kastellakis A, Spyraki C.Dizocilpine (MK-801) and tetrodotoxin influence accumbal dopamine release evokes by intrapallidal morphine [J]. Eur Neuropsy chopharmacol, 1998;8:47-53
[8] 郭松. 中药福康片与盐酸可乐定治疗阿片类戒断症状的临床对照研究[J].中国药物依赖性通报, 1995;4:210-6
[9] 王小平. 参附脱毒胶囊治疗海洛因依赖者戒断症状对照研究[J].中国药物依赖性杂志, 2002;11:120-4
[10] 韩济生. 关于海洛因成瘾问题的思考[J].中国科学院院刊, 1999;5:353-5
[11] Niveau G, Rougemont AL, La Harpe R.Methadone maintenance treatment, criminality and overdose-related deaths.An ecological study, 1983 -1999[J].Eur J Public Health, 2002;12:224-7
[12] Ghodse H, Oyefeso A, Kilpatrick B.Mortality of drug addicts in the United Kingdom 1967 - 1993[J].Int J Epidemiol, 1998;27:473-8
[13] Ciccocioppo R, Martin-Fardon R, Weiss F.Effect of selective blockade of mu(1) or delta opioid receptors on reinstatement of alcohol-seeking behavior by drug-associated stimuli in rats[J].Neuropsy chopharmacology, 2002;27:391-9
[14] FundytusME, Schiller PW, Shapiro M, et al.Attenuation of morphine tolerance and dependence with the highly selectiveδ-opioid receptor antagonist TIPP(Χ) [J].Eur J Pharmacol, 1995;286:105-8
[15] 黄矛, 周丽华.狗牙花总碱防治吗啡依赖的药理作用[J].中国药物依赖性杂志, 2001;10:8-10
[16] Janda KD.New directions in immunopharmacotherapy [J]. Ernst Schering Res Found Workshop, 2000;32:315-6
[17] Akbarzadeh A, Mehraby M, Zarbakhsh M, et al.Design and synthesis of a morphine-6-succinyl-bovine serum albumin hapten for vaccine development[J].Biotechnol Appl Biochem, 1999; 30:139-45
[18] Landry DW, Zhao K, Yang GX, et al.Antibody-catalyzed degradation of cocaine[J].Science, 1993;259:1899-901
[19] Matsushita M, Hoffman TZ, Ashley JA, el at.Cocaine catalytic antibodies:the primary importance of linker effects[J].Bioorg Med Chem Lett, 2001;22:87-90
[20] Myers WE Glasel JA.Subclass specificity of anti-idiotypic antiopiate receptor in rat brain, guinea pig cerebellum, & neuroblastoma x glioma (NG 108-15) [J].Life Sci, 1985;36:2523-9
[21] Coscia CJ, SzucsM, Barg J, et al.A monoclonal anti-idiotypic antibody to mu and delta opiod receptors[J].Brain ResMol Brain Res, 1991;9:299-306