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中国临床药理学与治疗学 ›› 2003, Vol. 8 ›› Issue (1): 55-58.

• 研究原著 • 上一篇    下一篇

盐酸西布曲明对营养性肥胖大鼠的减肥作用

陈光亮, 李莉, 严尚学1, 黄德武1   

  1. 安徽中医学院药理学教研室, 合肥 230038, 安徽; 1安徽医科大学实验动物中心, 合肥 230032, 安徽
  • 收稿日期:2002-08-23 修回日期:2002-09-10 出版日期:2003-02-26 发布日期:2020-11-25
  • 通讯作者: 陈光亮, 男, 副教授, 硕士生导师, 在职博士生, 主要从事中药药理研究及新药开发。Tel:0551-5112201 E-mail:chguangl@mail.hf.ah.cn

Anti-obesity effect of sibutramine hydrochloride in alimentary obesity rats

CHEN Guang-Liang, LI Li, YAN Shang-Xue1, HUANG De-Wu1   

  1. Department of Pharmacology, Anhui College of TCM, Hefei 230038, Anhui; 1Center of Experimental Animal, Anhui Medical University, Hefei 230032, Anhui
  • Received:2002-08-23 Revised:2002-09-10 Online:2003-02-26 Published:2020-11-25

摘要: 目的: 研究盐酸西布曲明对营养性肥胖大鼠的减肥作用。方法: 给刚断乳的SD 大鼠饲喂营养性饲料, 7 wk 后养成营养性肥胖模型, 分组给药, 连续6 wk。结果: 盐酸西布曲明9.0、3.0、1.0 mg·kg-1灌胃给药, 能明显降低肥胖大鼠体重、Lee's 指数和脂肪重量, 降低血清甘油三酯水平, 抑制脂肪细胞增大, 但对肥胖大鼠空肠绒毛的密度和肠绒毛直径无明显影响。结论: 盐酸西布曲明灌胃给药对营养性肥胖大鼠有显著的减肥降脂作用。

关键词: 盐酸西布曲明, 营养性肥胖, 大鼠, 减肥

Abstract: AIM: To investigate the anti-obesity effect of sibutramine hydrochloride in alimentary obesity rats. METHODS: The alimentary obesity models were established by hyperalimentation for 7 wk in just ablactating SD rats, and then the models were divided into several groups. RESULTS: Sibutramine hydrochloride 9.0, 3.0, and 1.0mg·kg -1 ig for 6 wk could significantly decrease body weight, Lee's index, total weight of celiac fat tissue as well as the size of adipocyte, and reduce the level of serum triglyceride in the simple obese rats.But no effect was shown on the density and diameter of jejunum villus. CONCLUSION: Sibutramine hydrochloride is an effective agent of anti-obesity effect in alimentary obesity rats.

Key words: sibutramine hydrochloride, alimentary obesity, rat, weight loss

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