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中国临床药理学与治疗学 ›› 2003, Vol. 8 ›› Issue (1): 95-97.

• 研究原著 • 上一篇    下一篇

伊贝沙坦对慢性肾小球肾炎患者血压和尿蛋白排泄的影响

刘宏, 余济荣, 刘必成, 王艳丽, 尹莲芳, 张晓良   

  1. 东南大学肾脏病研究所, 附属中大医院肾脏科, 南京 210009, 江苏
  • 收稿日期:2002-10-07 修回日期:2002-10-18 发布日期:2020-11-25
  • 通讯作者: 刘必成, 男, 副教授, 硕士生导师, 东南大学肾脏病研究所所长, 江苏省肾病学会副主任委员, 国际、美国肾病学会会员, 主要研究方向为肾脏纤维化的发病机制。Tel:025-3272137 E-mail:kidney@jlonline.com
  • 作者简介:刘宏, 男, 硕士研究生。Tel:025-3200084 E-mail:jstzliu@sina.com

Influence of irbesartan on blood pressure and proteinuria in patients with chronic glomerulonephritis

LIU Hong, YU Ji-Rong, LIU Bi-Cheng, WANG Yan-Li, YIN Lian-Fang, ZHANG Xiao-Liang   

  1. Institute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, Jiangsu
  • Received:2002-10-07 Revised:2002-10-18 Published:2020-11-25

摘要: 目的: 观察伊贝沙坦对慢性肾小球肾炎患者的血压、尿蛋白排泄的影响。方法: 27 例慢性肾小球肾炎患者应用伊贝沙坦治疗8 wk, 观察治疗前后血压、尿蛋白、肾功能、血钾、肝功能和血脂的变化。结果: 与伊贝沙坦治疗前相比, 治疗后血压、24 h 尿蛋白定量显著下降, 对肾功能、血钾、肝功能和血脂无影响。结论: 伊贝沙坦对慢性肾小球肾炎患者具有平稳显著的降压、降蛋白尿作用, 继而发挥肾保护作用。

关键词: 药效学, 伊贝沙坦, 慢性肾小球肾炎, 高血压, 蛋白尿

Abstract: AIM: To investigate the influence of irbesartan on blood pressure and proteinuria in patients with chronic glomerulonephritis. METHODS: 27 patients with chronic glomerulonephritis were treated with irbesartan for 8 wk.Blood pressure, proteinuria, renal function, serum K+, liver function, and serum lipid were detected before and after 8 wk. RESULTS: The levels of blood pressure and 24 h proteinuria were decreased significantly (P <0.01) 8 wk after the administration, but the renal function, serum K+, liver function and serum lipid were unchanged. CONCLUSION: Irbesartan shows a stable anti-hypertensive effect and can reduce proteinuria in patients with chronic glomerulonephritis.

Key words: pharmacoidynamics, irbesartan, chronic glomerulonephritis, hypertension, proteinuria

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