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中国临床药理学与治疗学 ›› 2003, Vol. 8 ›› Issue (3): 308-310.

• 研究原著 • 上一篇    下一篇

中药黄白液抑制Ⅱ型单纯疱疹病毒复制的实验研究1

杨志波, 欧阳恒, 欧柏生, 谭金华   

  1. 湖南中医学院附二院皮肤科, 长沙 410005, 湖南
  • 收稿日期:2002-11-16 修回日期:2003-01-17 出版日期:2003-06-26 发布日期:2020-11-25
  • 作者简介:杨志波, 男, 硕士, 主任医师, 硕士生导师, 主要从事性传播疾病的临床与实验室工作。Tel:0731-4917754 E-mail:yangzhibo -1@hotmail.com
  • 基金资助:
    1 湖南省教育厅基金项目(№01C228)

Experimental study on the inhibition of huangbaiye on HSV-2 in vitro

YANG Zhi-Bo, OUYANG Heng, OU Bai-Sheng, TAN Jin-Hua   

  1. Departmrnt of Dermatology, Second Affiliated Hospital, Hunan Chinese Medical College, Changsha 410005, Hunan
  • Received:2002-11-16 Revised:2003-01-17 Online:2003-06-26 Published:2020-11-25

摘要: 目的: 探讨黄白液治疗预防复发性生殖器疱疹的作用。方法: 采用体外细胞培养技术观察黄白液对Ⅱ型单纯疱疹病毒(HSV-2) 复制的抑制作用,并与环胞苷、阿昔洛韦作比较。结果: 黄白液对HSV-2 的复制有明显抑制作用, 其最小有效浓度为2.5 g·L-1, 治疗指数为3, 黄白液2.5 g·L-1对HSV-2的抑制作用不亚于环胞苷, 两者抑毒指数为2.83,阿昔洛韦抗HSV-2 作用较强, 抑制指数为5.31。结论: 黄白液可治疗复发性生殖器疱疹, 与其抑制HSV-2 的复制有关。

关键词: 药效学, 黄白液, 复发性生殖器疱疹, 抑制, Ⅱ型单纯疱疹病毒

Abstract: AIM: To study the effects of the huangbaiye in the treatment of recurrent genital herpes. METHODS: The inhibitory activity of huangbaiye on HSV-2 was observed from the cells cultured in vitro in comparison with cyclo-C and acyclovir. RESULTS: The huangbaiye showed notable direct inhibitory effects on HSV-2 in vitro.The minimal effective concentration was 2.5 g·L -1, the therapeutic index was 3, the inhibitory activity of huangbaiye (2.5 g·L -1 ) was not less than that of cyclo-C, and the inhibition virus index was 2.83 in both huangbaiye and cyclo-C. CONCLUSION: Huangbaiye has inhibitory affect on HSV-2 in the treatment of recurrent genital herpes.

Key words: pharmacodynamics, huangbaiye, recurrent genital herpes, inhibitory, herpes virus Ⅱ

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