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中国临床药理学与治疗学 ›› 2003, Vol. 8 ›› Issue (4): 370-373.

• 综述与讲座 • 上一篇    下一篇

凋亡抑制因子生存素的研究进展

陈艳萍, 毕富勇   

  1. 皖南医学院生物化学教研室,芜湖 241001,安徽
  • 收稿日期:2003-03-10 修回日期:2003-03-18 出版日期:2003-08-26 发布日期:2020-11-19
  • 通讯作者: 毕富勇,男,副教授,硕士生导师,研究方向:低分子RNA对白血病细胞代谢调控作用的研究。Tel:0553-3832468-6262 E-mail:bifuyong@yahoo.com.cn
  • 作者简介:陈艳萍,女,硕士生,专业方向:肿瘤生化。Tel:0553-3832468-6262 E-mail:janechenqd@163.com

Advances in study of new antiapoptosis factor :survivin

CHEN Yan-Ping, BI Fu-Yong   

  1. Department of Biochemistry,Wannan Medical College,Wuhu 241001,Anhui,China
  • Received:2003-03-10 Revised:2003-03-18 Online:2003-08-26 Published:2020-11-19

摘要: 生存素(survivin)是新近发现的一个IAP家族的独特成员,表达于胚胎组织和多种癌组织,但不见于正常组织。能抑制各种因子诱导的细胞凋亡,并参与血管生成,作为一种普遍表达的肿瘤特异性凋亡抑制因子,生存素可能是肿瘤靶基因蛋白治疗的理想靶点。

关键词: 综述, 生存素, 肿瘤, 细胞凋亡, 血管生成

Abstract: Survivin has been identified recently as a unique member of the inhibitor of apoptosisProtein family.It is expressed during fetal development and in all common human cancers,but not in normal tissues.It can inhibit apoptosis induced by a variety of factors andPlay an important role during angiogenesis.Being a universal tumor-specific antiapoptosis inhibitor,survivin may serve as aPotential target for gene-protein-based therapy of tumor.

Key words: review, survivin, tumor, apoptosis, angiogenesis

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