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中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (7): 744-746.

• 研究原著 • 上一篇    下一篇

顺铂与环磷酰胺联合应用剂量优化的实验研究

郭维, 崔景荣   

  1. 北京大学天然药物及仿生药物国家重点实验室, 北京100083
  • 收稿日期:2004-04-09 修回日期:2004-06-04 出版日期:2004-07-26 发布日期:2020-11-20
  • 通讯作者: 崔景荣,女,教授,硕士生导师,研究方向:抗肿瘤和免疫调节药物筛选、药效学和药物作用机制研究。Tel/Fax:010-82802467 E-mail:jrcui@mail.bjmu.edu.cn
  • 作者简介:郭维,女,讲师,研究方向:抗肿瘤药物的研究。

Does selection of combination treatment of cisplatin and cyclophosphamide

GUO Wei, CUI Jing-Rong   

  1. National Research Laboratory of Natural and Biomimetic Drugs, Beijing 100083, China
  • Received:2004-04-09 Revised:2004-06-04 Online:2004-07-26 Published:2020-11-20

摘要: 目的: 观察低剂量顺铂(DDP)和环磷酰胺(DTX)联合用药治疗恶性肿瘤疗效及其对免疫器官的毒性。方法: 采用小鼠肉瘤S180进行体内实验,观察两药单独及联合使用对小鼠S180 及胸腺和脾脏的影响。结果: DDP组和不同剂量的DTX 配伍应用与DDP组相比抑瘤率分别提高13.6%~29.6%,与相应剂量DTX 组相比抑瘤率分别提高33.5 % ~34.3 %,其中DDP+DTX 0.75 +7.5mg·kg-1组与DDP及相应剂量DTX 组相比较有显著意义(P<0.01~0.001);DDP组及两药联合应用各剂量组使小鼠胸腺指数和脾指数明显低于对照组。结论: 低剂量DDP与DTX 联合使用加强了对肿瘤生长的抑制作用,与DDP组相比,联合应用引起的免疫器官的萎缩与DDP组无差别。

关键词: 顺铂, 环磷酰胺, 肉瘤180, 毒副作用, 小鼠

Abstract: AIM: To investigate the anticancer effects and toxicity of cisplatin and cyclophosphamide used alone and in combination in treatment of the mice models with sarcoma 180 (S180).METHODS: The anticancer effects and toxicity were evaluated by the inhibition rate, the indexes of thymus and spleen.The growth of tumor was observed by mice models of transplant tumor.RESULTS: The inhibition rate of co-treatment of cisplatin(5.0mg·kg-1) and cyclophosphamide (7.5 mg·kg-1) increased 13.6 % -29.6 %, and 33.5 % -34.3 % in comparison with cisplatin and cyclophosphamide, respectively.The inhibition rate in the groups of co-treated was higher than that of in the group of cisplatin and cyclophosphoamide(7.5mg·kg-1) (P<0.01-0.001).CONCLUSION: Co-treatment of cisplatin in lower dose with cyclophosphamide shows a synergetic anticancer effect in mice models.

Key words: cisplatin, cyclophosphamide, sarcoma 180, toxicity, mice

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