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中国临床药理学与治疗学 ›› 2004, Vol. 9 ›› Issue (9): 988-991.

• 研究原著 • 上一篇    下一篇

缬沙坦对自发性高血压大鼠心肌抑癌基因PTEN 表达的影响

张捷, 刘昌慧, 何勇, 魏春阳, 王绍华   

  1. 武汉大学人民医院老年病科, 武汉430060, 湖北
  • 收稿日期:2004-07-06 修回日期:2004-08-12 出版日期:2004-09-26 发布日期:2020-11-23
  • 通讯作者: 刘昌慧, 女, 教授, 主任医师, 硕士生导师, 研究方向:老年心血管疾病。Tel:027-88041919-2906 E-mail:changhuiliu65@yahoo. com. cn
  • 作者简介:张捷, 女, 硕士研究生, 研究方向:老年心血管病。Tel:027-88075814 E-mail:shineyoung2000 @126. com

Effects of valsartan on phosphatase and tensin homologue deleted on chromosome ten (PTEN) in spontaneously hypertensive rats

ZHANG Jie, LIU Chang-Hui, HE Yong, WEI Chun-Yang, WANG Shao-Hua   

  1. Department of Gerontology, Renmin Hospital, Wuhan University, Wuhan 430060, Hubei, China
  • Received:2004-07-06 Revised:2004-08-12 Online:2004-09-26 Published:2020-11-23

摘要: 目的: 观察缬沙坦对自发性高血压大鼠(SHR) 心肌肥厚的影响, 以及对肿瘤抑制基因PTEN表达的影响。方法: 取20 只12 周龄自发性高血压大鼠, 随机分为2 组, 每组10 只:缬沙坦干预组, 给予缬沙坦30 mg·kg-1·d-1 溶于饮水灌胃治疗;SHR阳性对照组给予正常饮水。另有10 只同龄同源雄性正常血压Wistar-kyoto 大鼠(WKY 组) 作为正常对照组。实验周期8 周, 测量血压、左室重量 体重(LVW/BW), 应用免疫组化方法检测各组大鼠左心室心肌PTEN 的表达。结果: SHR 阳性对照组血压、LVW/BW 均高于正常对照组, 但低于缬沙坦组, SHR阳性对照组PTEN 的表达明显低于正常对照组, 而缬沙坦组PTEN 的表达显著高于SHR 阳性对照组。结论: 缬沙坦能抑制自发性高血压大鼠心肌肥厚, 并能提高PTEN 的表达, 提示PTEN 可能在心肌肥厚发展过程中起了一定的作用。

关键词: PTEN, 高血压, 自发性高血压大鼠, 心肌肥厚, 缬沙坦

Abstract: AIM: To observe the effects of valsartan on the cardiac hypertrophy and the expression of PTEN in spontaneously hypertensive rats (SHR).METHODS: Twenty 12-week-old male SHRwere randomly divided into 2 groups: SHR positive control group and valsartan treating group (30 mg·kg-1·d-1). 10 homogenous Wistar-kyoto (WKY) rats were served as normal control group. Blood pressure and the ratio of left ventricular weight to body weight(LVW/BW) of rats were monitored periodically during the 8-weeks studies. Expression of PTEN in cardiac myocytes was determined by immunohistochemistry.RESULTS: Blood pressure and LVW/BW increased in the valsartan group more than those in the SHR control group, and the expression of PTEN in cardiac myocytes in valsartan group increased more than that in the SHR control group, but the indexes were lower than those in the WKY group.CONCLUSION: Valsartan can not only inhibit the progression of cardiac hypertrophy in spontaneously hypertensive rats, but also increase the expression of PTEN. PTEN may play a role in cardiac hypertrophy.

Key words: PTEN, hypertension, SHR, cardiac hypertrophy, valsartan

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